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DEVELOPMENT OF A HANDHELD INTEGRATED DYNAMIC IMAGING SYSTEM AND REMOTE VESSEL OCCLUDER FOR CANCER DETECTION AND TREATMENT

ElDahdah, Hamid Joseph

Abstract Details

2009, Master of Science, Ohio State University, Biomedical Engineering.
The first part of the research is dedicated to the diagnosis of breast cancer with the aid of imaging technologies. The Dynamic Breast Imaging System (DBIS) is an innovative medical device for analyzing the structural and physiologic characteristics of breast tissue and for characterizing/differentiating malignant tumors, benign tumors, and normal breast tissue. This research constructed a handheld probe and corresponding software that simultaneously uses ultrasound and near-infrared light in a dynamic fashion to detect and characterize tissue properties. The combined usage of physiologic and structural data provides a holistic view of the properties of breast tissue and suspicious lesions and aid in image reconstruction. The DBIS probe incorporates pressure sensors to allow the operator to make cyclic compression patterns for breast tissue characterization. Several benchtop tests were conducted to test the system's efficiency, reliability and reproducibility. We are currently planning gathering data through clinical trials at the James Cancer Hospital in Dublin Ohio. The second part of the research focuses on cancer treatment with the development of an innovative occlusion device used in conjunction with ablation processes. It is observed, by controlling the blood flow to a region of interest, one can significantly affect the coagulation lesion size during cancer ablation procedures. We describe the design, development and validation of a remote vessel occlusion device that quantitatively controls vascular perfusion in a repeatable fashion. The occlusion device consists of a flexible cannula containing a shape memory alloy wire with its proximal end tied to a surgical suture and its distal end connected to a driver circuit. The electronic circuit regulates the voltage in the memory alloy wire controlling its amount of reduction in length, tightening the surgical suture. To validate the quantitative control of blood flow, the vessel occluder ligated a vessel simulator that underwent perfusion with dilute porcine blood at five different occlusion levels. The ligation device was then tested for repeatability on a wild type mouse where a cyclic pattern of vessel occlusion and release was performed on the mouse‟s femur artery. The device was further tested on a cancer mouse model that had a cancerous growth on its leg. During ligation of the simulated vessel, a linear correlation between the occluder voltage and the resultant vascular blood flow was observed. For the tests on the wild type mouse and cancer mouse model, corresponding changes in tissue oxygen and hemoglobin concentrations were detected using an oximeter. Future work includes a wider range of occlusion levels to achieve a continuous change in blood flow and better portability.
Ronald Xu, PhD (Advisor)
Kun Huang, PhD (Committee Member)
96 p.

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Citations

  • ElDahdah, H. J. (2009). DEVELOPMENT OF A HANDHELD INTEGRATED DYNAMIC IMAGING SYSTEM AND REMOTE VESSEL OCCLUDER FOR CANCER DETECTION AND TREATMENT [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1248379683

    APA Style (7th edition)

  • ElDahdah, Hamid. DEVELOPMENT OF A HANDHELD INTEGRATED DYNAMIC IMAGING SYSTEM AND REMOTE VESSEL OCCLUDER FOR CANCER DETECTION AND TREATMENT. 2009. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1248379683.

    MLA Style (8th edition)

  • ElDahdah, Hamid. "DEVELOPMENT OF A HANDHELD INTEGRATED DYNAMIC IMAGING SYSTEM AND REMOTE VESSEL OCCLUDER FOR CANCER DETECTION AND TREATMENT." Master's thesis, Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1248379683

    Chicago Manual of Style (17th edition)