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Behavioral and Physiological Responses To Lipopolysaccharide Induced Clinical Mastitis

Zimov, Jennifer Laura

Abstract Details

2009, Master of Science, Ohio State University, Animal Sciences.
The behavioral and physiological effects of lipopolysaccharide induced mastitis were examined in lactating Holstein cows. Twenty cows were assigned to five blocks of four cows grouped by parity and stage of lactation. The experimental design for this study was a 2 X 2 factorial arrangement. Cows within the blocks were randomly assigned to one of four treatments: 1) intramammary infusion with 25 µg lipopolysaccharide and intravenous flunixin meglumine; 2) intramammary infusion with 25 µg lipopolysaccharide and intravenous PBS; 3) intramammary infusion with PBS and intravenous flunixin meglumine; and 4) intramammary infusion PBS and intravenous with PBS. Uninfected mammary quarters were infused 3 h post milking. Intravenous treatments were given 7 h post milking. Experimental cows were under continuous video monitoring during the study. Cows receiving the lipopolysaccharide treatment had higher mean peak quarter milk somatic cell counts, rectal temperatures, concentrations of milk amyloid and serum cortisol during the first 12 h after infusion compared with intramammary saline treated cows. Lipopolysaccharide treated cows spent a reduced percentage of the first 24 h after challenge eating and cud chewing compared with saline infused cows. Rumen contractions were reduced in lipopolysaccharide infused cows compared with saline infused cows at sample times corresponding with peak rectal temperatures. Flunixin treatment 4 h after intramammary challenge mitigated the clinical systemic responses of increased rectal temperature and decreased rumen activity. Cows receiving LPS infusion and treatment with flunixin spent more time eating the first 12 h after challenge than animals receiving infusion of LPS and treatment of PBS. Flunixin treatment increased time spent cud chewing in all cows. Acute clinical mastitis changed physiological and behavioral parameters in lactating dairy cows. The administration of flunixin meglumine mitigated the adverse systemic affects associated with LPS induced mastitis.
Joseph Hogan (Advisor)
William Weiss (Committee Member)
Steven Moeller (Committee Member)
65 p.

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Citations

  • Zimov, J. L. (2009). Behavioral and Physiological Responses To Lipopolysaccharide Induced Clinical Mastitis [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1253132975

    APA Style (7th edition)

  • Zimov, Jennifer. Behavioral and Physiological Responses To Lipopolysaccharide Induced Clinical Mastitis. 2009. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1253132975.

    MLA Style (8th edition)

  • Zimov, Jennifer. "Behavioral and Physiological Responses To Lipopolysaccharide Induced Clinical Mastitis." Master's thesis, Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1253132975

    Chicago Manual of Style (17th edition)