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Interactive Effect of the Serotonin Transporter 5-HTTLPR Genotype and Chronic Stress on Depressive Symptoms in Postmenopausal Women

Hantsoo, Liisa Victoria
http://rave.ohiolink.edu/etdc/view?acc_num=osu1266260369

Abstract Details

2010, Master of Arts, Ohio State University, Psychology.
The short (s) allele of the serotonin transporter gene length polymorphism (5-HTTLPR) is associated with depression when combined with stress, in a gene by environment interaction model. This research examined the relationship between the 5-HTTLPR gene and caregiving stress on symptoms of depression in postmenopausal women. The sample included 105 female controls and 79 female dementia caregivers. Depressive symptomatology was assessed with the Center for Epidemiologic Studies Depression Scale (CES-D). Results showed that the gene by environment interaction was not significant (p=0.167) in postmenopausal women, although there was a main effect for caregiver status, such that caregivers showed higher CES-D scores than controls (p<0.001). When comparing premenopausal women to postmenopausal women, the three-way gene by environment by menopausal status interaction was not significant (p=0.711), nor was the gene by environment interaction (p=0.140). However, there was a main effect for caregiver status such that caregivers exhibited higher CES-D scores compared to controls (p=0.003). Results suggest that postmenopausal women undergoing caregiving stress exhibit higher levels of depressive symptomatology regardless of genotype, and that female caregivers are more depressed than female controls regardless of menopausal status.
Janice Kiecolt-Glaser, Ph.D. (Advisor)
Charles Emery, Ph.D. (Committee Member)
Michael Vasey, Ph.D. (Committee Member)
130 p.
Psychology
serotonin transporter gene; 5-HTTLPR; women's health; depression; gene x environment interaction model

Recommended Citations

Citations

  • Hantsoo, L. V. (2010). Interactive Effect of the Serotonin Transporter 5-HTTLPR Genotype and Chronic Stress on Depressive Symptoms in Postmenopausal Women [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1266260369

    APA Style (7th edition)

  • Hantsoo, Liisa. Interactive Effect of the Serotonin Transporter 5-HTTLPR Genotype and Chronic Stress on Depressive Symptoms in Postmenopausal Women. 2010. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1266260369.

    MLA Style (8th edition)

  • Hantsoo, Liisa. "Interactive Effect of the Serotonin Transporter 5-HTTLPR Genotype and Chronic Stress on Depressive Symptoms in Postmenopausal Women." Master's thesis, Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1266260369

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.