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Uni- or Bi- Ventricular Hypertrophy and Susceptibility to Drug- induced Torsades de Pointes

Panyasing, Yaowalak
http://rave.ohiolink.edu/etdc/view?acc_num=osu1279381163

Abstract Details

2010, Master of Science, Ohio State University, Veterinary Biosciences.
Cardiac hypertrophy is an independent risk factor for torsades de pointes (TdP), a polymorphic ventricular tachycardia that is often drug-induced, but that may terminate spontaneously or evolve into ventricular fibrillation and sudden death. People with ventricular hypertrophy or heart failure have an increased risk of drug-induced arrhythmias, therefore this study was designed to determine if right (RVH), left (LVH), or biventricular (BVH) hypertrophy increases susceptibility to drug-induced TdP. Rabbits were separated into 4 groups: control or RVH, LVH, BVH (studied 8 weeks after banding of one or both great arteries). ECGs were recorded continuously after baseline and after rabbits received escalating doses of torsadogens (dofetilide, clofilium and terfenadine) or non-torsadogens (cilobradine, diltiazem and vehicle). The following parameters were measured [RR, PQ, QRS, and QT] or calculated [QTc (F), short term variability of QT interval]. Generally, torsadogenicity for the compounds tested was dofetilide > clofilium > terfenadine, and there was no TdP following cilobradine, diltiazem or vehicle. In general the susceptibility to TdP was RVH > BVH > LVH > control. Rabbits with RVH developed TdP much more prevalently than for those with either LVH or BVH (p < 0.05). At low doses of dofetilide, LVH was actually protective. Rabbits with any form of hypertrophy develop prolongation of QT, QTc and increased QT instability. Rabbits with any form of hypertrophy are more prone to arrhythmia than normals in response to known torsadogens.
Robert Hamlin (Advisor)
Stephen Strauch (Committee Member)
Cynthia Carnes (Committee Member)
58 p.
Biomedical Research
hypertrophy; rabbits; torsades de pointes

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Citations

  • Panyasing, Y. (2010). Uni- or Bi- Ventricular Hypertrophy and Susceptibility to Drug- induced Torsades de Pointes [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1279381163

    APA Style (7th edition)

  • Panyasing, Yaowalak. Uni- or Bi- Ventricular Hypertrophy and Susceptibility to Drug- induced Torsades de Pointes. 2010. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1279381163.

    MLA Style (8th edition)

  • Panyasing, Yaowalak. "Uni- or Bi- Ventricular Hypertrophy and Susceptibility to Drug- induced Torsades de Pointes." Master's thesis, Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1279381163

    Chicago Manual of Style (17th edition)

osu1279381163
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© 2010, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.