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Sex Differences in Inflammation, Psychological Functioning, and Disease Outcomes Among COPD Patients Participating in Pulmonary Exercise Rehabilitation

Busby, Andrea Kristin
http://rave.ohiolink.edu/etdc/view?acc_num=osu1281625905

Abstract Details

2010, Doctor of Philosophy, Ohio State University, Psychology.
Studies indicate that women may have a greater risk of diagnosis with chronic obstructive pulmonary disease (COPD) as well as poorer disease outcomes than men. Systemic inflammation has been hypothesized as a critical factor in this sex difference. This study evaluated sex differences in systemic inflammation among men and women with COPD (N=23) prior to and after participation in pulmonary exercise rehabilitation. Before and after rehabilitation participation, participants had blood drawn to measure serum interleukin-6 (IL-6), and participants completed self-report measures of depression, anxiety, quality of life, and dyspnea, as well as standardized assessments of physical fitness. It was hypothesized that women would have higher levels of systemic inflammation, psychological distress, and dyspnea, and lower levels of quality of life and physical fitness at baseline compared with men. In addition, it was hypothesized that men would experience significantly greater improvements on most outcome variables after participating in exercise rehabilitation. Further, it was hypothesized that age, sex, and psychological distress would moderate the relationship between changes in physical fitness and changes in systemic inflammation. Results indicated that women reported higher levels of psychological distress than men at baseline, but that men and women did not differ in terms of systemic inflammation at baseline. In addition, both men and women experienced improvements in multiple outcome variables following exercise rehabilitation. There was limited evidence of any additional improvement for men, beyond that experienced by women, and neither group experienced changes in systemic inflammation as a result of exercise rehabilitation. However, women experienced greater increases in inflammation associated with improvement in physical endurance. Pearson correlations revealed that IL-6 was positively correlated with weight and negatively correlated with pulmonary functioning. However, IL-6 was also positively correlated with subjective vitality and negatively correlated with age. The results of this study indicate that men and women benefit from pulmonary exercise rehabilitation in multiple disease-relevant domains, but that systemic inflammation may be more closely related to lung functioning than to functional performance, quality of life, or distress. Thus, an 8-week exercise rehabilitation program may have limited impact on inflammation in this population, and may contribute to short-term increases in inflammation among women. Future research is needed to more fully explore the relationship between COPD, inflammation, pulmonary functioning, and exercise training.
Charles Emery, Ph.D. (Advisor)
Janice Kiecolt-Glaser, Ph.D. (Committee Member)
Michael Vasey, Ph.D. (Committee Member)
Timothy Buckley, Ph.D. (Committee Member)
117 p.
Psychology
COPD; inflammation; sex differences; pulmonary rehabilitation; depression; anxiety; quality of life

Recommended Citations

Citations

  • Busby, A. K. (2010). Sex Differences in Inflammation, Psychological Functioning, and Disease Outcomes Among COPD Patients Participating in Pulmonary Exercise Rehabilitation [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1281625905

    APA Style (7th edition)

  • Busby, Andrea. Sex Differences in Inflammation, Psychological Functioning, and Disease Outcomes Among COPD Patients Participating in Pulmonary Exercise Rehabilitation. 2010. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1281625905.

    MLA Style (8th edition)

  • Busby, Andrea. "Sex Differences in Inflammation, Psychological Functioning, and Disease Outcomes Among COPD Patients Participating in Pulmonary Exercise Rehabilitation." Doctoral dissertation, Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1281625905

    Chicago Manual of Style (17th edition)

osu1281625905
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© 2010, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.