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Towards the total synthesis of Azaspiracid-3

Yue, Ding
http://rave.ohiolink.edu/etdc/view?acc_num=osu1284488476

Abstract Details

2010, Doctor of Philosophy, Ohio State University, Chemistry.
A novel tert-butyl lithium mediated ring closure strategy was described in the synthesis of the carbon skeleton of azaspiracid-3. This novel strategy disconnected the compound into two fragments. The synthesis of both fragments was described. Because of reactivity issues, some protecting group must be altered before the coupling could be achieved. After coupling, the key ring closure proceeded as expected. Some purification techniques were needed in order to achieve the total synthesis of azaspiracid-3.
Craig Forsyth (Advisor)
Dehua Pei (Committee Member)
Anita Mattson (Committee Member)
211 p.
Chemistry
azaspiracid synthesis intramolecular Barbier type reaction

Recommended Citations

Citations

  • Yue, D. (2010). Towards the total synthesis of Azaspiracid-3 [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1284488476

    APA Style (7th edition)

  • Yue, Ding. Towards the total synthesis of Azaspiracid-3. 2010. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1284488476.

    MLA Style (8th edition)

  • Yue, Ding. "Towards the total synthesis of Azaspiracid-3." Doctoral dissertation, Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1284488476

    Chicago Manual of Style (17th edition)

osu1284488476
380
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This open access ETD is published by The Ohio State University and OhioLINK.