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AMINOCAPROIC ACID FOR THE PREVENTION OF POSTOPERATIVE BLEEDING IN GREYHOUNDS

Marin, Liliana Marcela

Abstract Details

2011, Master of Science, Ohio State University, Veterinary Clinical Sciences.
Delayed postoperative bleeding is common in retired racing Greyhounds (RRGs), despite normal results of routine hemostasis assays. The excessive postoperative bleeding in the RRGs is not due to primary or secondary hemostatic defects, and may be due to enhanced fibrinolysis or to a clot maintenance dysfunction. Providing a method to prevent or minimize the severity of postoperative bleeding in RRGs will not only have major economic impact for owners, but also will markedly decrease the associated complications of minor or major surgeries in the breed. Epsilon aminocaproic acid (EACA) is a potent inhibitor of fibrinolysis that also supports clot maintenance due to unknown mechanisms. The objective of this double-blinded, prospective, randomized study was to evaluate the effects of EACA versus placebo on the prevalence of bleeding in RRGs, and to investigate its mechanism of action by using TEG. We compared the effects of EACA and placebo in 100 RRGs that underwent elective ovariohysterectomy or orchiectomy at the Veterinary Medical Center, The Ohio State University during 2 years. The main endpoint was bleeding (prevalence and severity); minor endpoints included most TEG parameters. Thirty percent (15/50) of the RRGs in the placebo group had delayed postoperative bleeding starting 36 to 48 hours after surgery, compared to 10% (5/50) in the EACA group (P= 0.0124). On the TEG parameters, the slopes for R and K time were significantly different between treatment groups (P=0.050); the R and K time decreased over time in the EACA group after surgery, while they increased in the placebo group. The angle, MA, and G slopes were also significantly different between treatment groups (P=0.001, 0.001, and 0.006, respectively). The angle, MA, and G increased postoperatively over time in the EACA group, while they decreased in the placebo group. All these changes are supportive of hypercoagulability associated with EACA administration. Therefore, the postoperative administration of EACA significantly decreased the prevalence of postoperative bleeding in RRGs by increasing the clot strength.
Guillermo Couto, DVM (Advisor)
Mary McLoughlin, DVM (Committee Member)
Julien Guillaumin, DVM (Committee Member)
54 p.

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Citations

  • Marin, L. M. (2011). AMINOCAPROIC ACID FOR THE PREVENTION OF POSTOPERATIVE BLEEDING IN GREYHOUNDS [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306419376

    APA Style (7th edition)

  • Marin, Liliana. AMINOCAPROIC ACID FOR THE PREVENTION OF POSTOPERATIVE BLEEDING IN GREYHOUNDS. 2011. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1306419376.

    MLA Style (8th edition)

  • Marin, Liliana. "AMINOCAPROIC ACID FOR THE PREVENTION OF POSTOPERATIVE BLEEDING IN GREYHOUNDS." Master's thesis, Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306419376

    Chicago Manual of Style (17th edition)