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Effects of Extensive Periosteal Stripping on the Microstructure and Mechanical Properties of Cortical Bone

Mercurio, Andrew David
http://rave.ohiolink.edu/etdc/view?acc_num=osu1306435727

Abstract Details

2011, Master of Science, Ohio State University, Comparative and Veterinary Medicine.
The periosteum is a thin connective tissue layer that covers the external surfaces of most bones and is essential to normal cortical bone biology. Periosteal stripping (PS) is a significant risk factor for post-radiation pathologic fracture following surgery for extremity soft tissue sarcomas. The purpose of this study was to determine the effects of PS on cortical bone structure and mechanical properties. 62 adult female mice underwent PS (N=32) or sham surgery (N=30) on the left femur. For PS, the periosteum was circumferentially removed from an 8-mm segment of the mid-diaphysis. For sham surgery, the bone was isolated without manipulation. At 2, 6, 12, or 26 weeks following surgery, the left femora were examined by micro-CT. Cortical thickness (CtTh), cross-sectional area (CSA), bone volume (BV) and polar moment of inertia (PMI) were measured from the mid-diaphysis. 3-point mechanical bend testing was performed and peak load (PL), stiffness and energy to failure (EF) were determined. Data from the groups were compared at each time point using a Student’s T-test (p<0.05), and two-way ANOVA was used to examine the parameters. PS resulted in significantly decreased CtTh, CSA, BV and PMI at all time points. PS resulted in significantly decreased PL, stiffness, and EF at 2 weeks, with further decreases at 6 and 12 weeks. There were no significant differences in mechanical properties between the two groups at 26 weeks. Correlation analysis revealed strong and significant relationships between microstructural and mechanical parameters. In conclusion, extensive PS causes early and significant decreases in cortical bone structural and mechanical properties, with eventual recovery of strength.
Matthew Allen, Vet MB, PhD (Advisor)
Eric Green, DVM, DACVR (Committee Member)
Joel Mayerson, MD (Committee Member)
36 p.
Biomedical Research
mouse; animal model; periosteum; micro-CT; fragility

Recommended Citations

Citations

  • Mercurio, A. D. (2011). Effects of Extensive Periosteal Stripping on the Microstructure and Mechanical Properties of Cortical Bone [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306435727

    APA Style (7th edition)

  • Mercurio, Andrew. Effects of Extensive Periosteal Stripping on the Microstructure and Mechanical Properties of Cortical Bone. 2011. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1306435727.

    MLA Style (8th edition)

  • Mercurio, Andrew. "Effects of Extensive Periosteal Stripping on the Microstructure and Mechanical Properties of Cortical Bone." Master's thesis, Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306435727

    Chicago Manual of Style (17th edition)

osu1306435727
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© 2011, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.