Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


osu1312907534.pdf (1.27 MB)

ETD Abstract Container

Abstract Header

Dopamine and Norepinephrine Transporter Inhibition in Cocaine Addiction: Using Mice Expressing Cocaine-Insensitive Transporters

Martin, Bradley J.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1312907534

Abstract Details

2011, Doctor of Philosophy, Ohio State University, Neuroscience Graduate Studies Program.
Cocaine’s effects are predominately mediated by inhibiting the reuptake transporters for dopamine, serotonin, and norepinephrine. How each of these transporters contributes to cocaine’s effects is unclear, but such knowledge would aid in efforts to design rational treatments for cocaine addiction. To directly test the contribution of each of these transporters in cocaine’s effects, three transgenic knockout mouse lines were previously created wherein each transporter gene was individually deleted. These knockout mice studies suggest that no single transporter is critical for mediating cocaine’s rewarding effects. However, this hypothesis contradicts pharmacological studies which indicate that the dopamine transporter (DAT) is critical for cocaine’s rewarding effects. Our lab hypothesized that the compensatory adaptations of knockout mice were responsible for this discrepancy. To avoid compensatory adaptations, our lab developed transporter knockin mice expressing a mutated, yet functional, transporter that is insensitive to cocaine inhibition. Unlike transporter knockout mice, these cocaine-insensitive transporter mice retain functioning neurotransmitter systems. We have previously used cocaine-insensitive dopamine transporter mice to reestablish the hypothesis that inhibiting the dopamine transporter is critical for cocaine’s rewarding effects.
Howard Gu, PhD (Advisor)
Robert Stephens, Jr./PhD (Committee Member)
Gary Wenk, PhD (Committee Member)
Lane Wallace, PhD (Committee Member)
104 p.
Neurobiology
cocaine; norepinephrine transporter; dopamine transporter; knockin mice; animal models; reward; stimulation; neuroadaptations

Recommended Citations

Citations

  • Martin, B. J. (2011). Dopamine and Norepinephrine Transporter Inhibition in Cocaine Addiction: Using Mice Expressing Cocaine-Insensitive Transporters [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1312907534

    APA Style (7th edition)

  • Martin, Bradley. Dopamine and Norepinephrine Transporter Inhibition in Cocaine Addiction: Using Mice Expressing Cocaine-Insensitive Transporters. 2011. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1312907534.

    MLA Style (8th edition)

  • Martin, Bradley. "Dopamine and Norepinephrine Transporter Inhibition in Cocaine Addiction: Using Mice Expressing Cocaine-Insensitive Transporters." Doctoral dissertation, Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1312907534

    Chicago Manual of Style (17th edition)

osu1312907534
840
© 2011, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.