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Development and Demonstration of Femtosecond Laser Micromachining Processes for Biomedical Applications

Lim, Yong Chae
http://rave.ohiolink.edu/etdc/view?acc_num=osu1313505193

Abstract Details

2011, Doctor of Philosophy, Ohio State University, Industrial and Systems Engineering.
Microscale materials fabrication processes are necessary for many applications. Clean room techniques can be used to fabricate micro/nano scale device for biomedical applications, but they require masking and multiple steps as well as hazardous chemical reagents. One of the non-clean room techniques that achieves microscale resolution is laser ablation, specifically femtosecond laser ablation. Laser ablation by pulses with duration on the sub-picosecond or femtosecond time scales can remove materials with lower residual thermal effect, and the accuracy and quality of the device is often superior to conventional longer-pulse lasers. Also, it provides a convenient, economical and flexible way to fabricate programmable 3-dimensional patterns by varying the beam scanning speed during ablation as well as laser pulse energy. In addition, femtosecond laser ablation technique can be combined with other fabrication techniques as a primary or a post process. In this dissertation, femtosecond laser micromachining technique was employed for microscale functional device fabrication with different materials to support biomedical researches. Femtosecond laser and material interaction properties, such as ablation threshold fluence, and incubation coefficient, were experimentally study for the bovine cortical bone and ethylene glycol dimethylacrylate (EGDMA) polymer. Ablation features were also characterized. Developed femtosecond laser micromachining was then used to fabricate microscale device for biomedical applications. Micropillar on bovine cortical bone was made for micromechanical test purpose. Inlet/outlet microchannels were made on EGDMA polymer for cell loading. Array of microwells were patterned on blended electrospun poly(ε-caprolactone)/gelatin (PCL/gelatin) nanofiber scaffolds for tissue engineering application. Microchannels were made on electrospun poly(ε-caprolactone) (PCL) nanofiber scaffolds for vascular tissue engineering application. Sub-micron size of pores were drilled on polyvinylidene fluoride (PVDF) thin membrane for nanoelectroporation.
Dave Farson (Advisor)
John Lannutti (Committee Member)
L. James Lee (Committee Member)
199 p.
Industrial Engineering; Materials Science; Nanotechnology
Femtosecond laser; Ablation; micromachining; biomedical application

Recommended Citations

Citations

  • Lim, Y. C. (2011). Development and Demonstration of Femtosecond Laser Micromachining Processes for Biomedical Applications [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313505193

    APA Style (7th edition)

  • Lim, Yong Chae. Development and Demonstration of Femtosecond Laser Micromachining Processes for Biomedical Applications. 2011. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1313505193.

    MLA Style (8th edition)

  • Lim, Yong Chae. "Development and Demonstration of Femtosecond Laser Micromachining Processes for Biomedical Applications." Doctoral dissertation, Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313505193

    Chicago Manual of Style (17th edition)

osu1313505193
2,152
© 2011, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.