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The Effects of Topical Nalbuphine on Canine Corneal Fibroblasts In Vitro

Spatola, Ronald Anthony
http://rave.ohiolink.edu/etdc/view?acc_num=osu1313702720

Abstract Details

2011, Master of Science, Ohio State University, Veterinary Biosciences.
Assessing the effects of novel topical ophthalmic medications on the viability and wound healing of corneal tissue is essential in ophthalmic pharmacology and therapeutics. The objective of this study was to evaluate the effects of a topical nalbuphine solution on canine corneal fibroblasts in vitro. Nalbuphine is a mixed agnoist-antagonist opioid medication that possesses kappa agonist and mu antagonist properties. It has recently been compounded into a 1.2% ophthalmic solution for use for the management of pain associated with diseases of the ocular surface in veterinary patients. Multiple concentrations of nalbuphine were assessed for their effects on viability and migration of cultured canine corneal fibroblasts at various time points. Solutions of 1% and 0.5 % nalbuphine proved to be acutely toxic to cultured canine corneal fibroblast, while lower concentrations exhibited less toxicity. The drug also delayed the migration of corneal fibroblasts at a concentration of 0.1%. Future studies are needed to assess the effects of nalbuphine solution on cultured canine corneal epithelial cell viability and migration, as well as in vivo pharmacologic and cytotoxic properties.
Heather Chandler, PhD (Advisor)
David Wilkie, DVM, MS (Committee Member)
Anne Gemensky-Metzler, DVM, MS (Committee Member)
79 p.
Ophthalmology
nalbuphine; corneal fibroblast; corneal wound healing

Recommended Citations

Citations

  • Spatola, R. A. (2011). The Effects of Topical Nalbuphine on Canine Corneal Fibroblasts In Vitro [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313702720

    APA Style (7th edition)

  • Spatola, Ronald. The Effects of Topical Nalbuphine on Canine Corneal Fibroblasts In Vitro. 2011. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1313702720.

    MLA Style (8th edition)

  • Spatola, Ronald. "The Effects of Topical Nalbuphine on Canine Corneal Fibroblasts In Vitro." Master's thesis, Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313702720

    Chicago Manual of Style (17th edition)

osu1313702720
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© 2011, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.