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A Histomorphometric Analysis of Muscular Insertion Regions: Understanding Enthesis Etiology

Schlecht, Stephen Harold
http://rave.ohiolink.edu/etdc/view?acc_num=osu1328985192

Abstract Details

2012, Doctor of Philosophy, Ohio State University, Anthropology.
The purpose of this study is to explore the relationship between tendon insertions, or entheses, and mechanically induced bone remodeling. Previous research suggests size and complexity of entheses are indicative of strain magnitude resulting from habitual physical activity. However, degree differences in the morphological expression of entheses has never been explicitly linked to activity intensity. Additional factors such as age, sex, and genetics potentially influence insertion morphology. This study investigates the relationship between enthesis location and mechanical loading, quantifying histomorphometric evidence for targeted remodeling related to applied strains in the non-weight bearing human radius. Thin sections from three diaphyseal regions of the radius associated with four muscle bodies responsible for forearm rotation were harvested from 14 human cadavers and prepared for histologic analysis. Specifically, cross-sections were removed from the right and left proximal, midshaft, and distal diaphysis where the biceps brachii, supinator, pronator teres, and pronator quadratus muscles respectively insert. Osteon population densities (OPD), or number of intact and fragmentary osteons per unit area, and osteon area (On.Ar) were quantified from eight cross-sectional zones defined by the principal anterioposterior and mediolateral axes, and their intersecting planes; encompassing all potential regions of tendon insertion. OPD reflects the visible remodeling history of compacta along each ray, and On.Ar reflects strain level. Interval mean plots confirm associations between OPD and On.Ar, demonstrating elevated bone turnover along rays aligned with three of the four considered entheses. The biceps brachii enthesis was not associated with increased remodeling, reflecting reduced cortical volume and calcified fibrocartilage present within the radial tuberosity, demonstrating composite and etiological differences between fibrous and fibrocartilaginous entheses. Findings from this investigation confirm a potential relationship between entheses and mechanical strain. However, other contributing factors remain elusive. Biological profiles that attribute enthesial morphology to general activity levels should be employed cautiously. Before the validity of their use can be confirmed, further investigation into additional mechanical and systemic influences is recommended.
Sam D. Stout, PhD (Committee Chair)
Clark S. Larsen, PhD (Committee Member)
Paul W. Sciulli, PhD (Committee Member)
162 p.
Biology; Biomechanics; Forensic Osteology; Human Remains; Physical Anthropology
enthesis; musculoskeletal stress markers; human radius; activity-patterns; histomorphometry; skeletal biology

Recommended Citations

Citations

  • Schlecht, S. H. (2012). A Histomorphometric Analysis of Muscular Insertion Regions: Understanding Enthesis Etiology [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1328985192

    APA Style (7th edition)

  • Schlecht, Stephen. A Histomorphometric Analysis of Muscular Insertion Regions: Understanding Enthesis Etiology. 2012. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1328985192.

    MLA Style (8th edition)

  • Schlecht, Stephen. "A Histomorphometric Analysis of Muscular Insertion Regions: Understanding Enthesis Etiology." Doctoral dissertation, Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1328985192

    Chicago Manual of Style (17th edition)

osu1328985192
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© 2012, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.