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Fatty Acid Desaturase (FADS) Genetic Variants and Dietary Polyunsaturated Fatty Acid Intake: Associations with Negative Affect

Hantsoo, Liisa
http://rave.ohiolink.edu/etdc/view?acc_num=osu1333466271

Abstract Details

2012, Doctor of Philosophy, Ohio State University, Psychology.
Background: Depressive symptomatology has been associated with polyunsaturated fatty acid (PUFA) levels in diet and tissue. However, results have been mixed, and studies have failed to account for genetic factors that may influence such associations. Tissue PUFA levels are strongly influenced by elongase and desaturase activity, which are governed by the fatty acid desaturase (FADS) genes. Inefficient desaturase activity has been associated with depression. Further, FADS genotypes have been associated with neuropsychological phenotypes such as postpartum depression. Given these associations, the study of relationships among dietary PUFA intake, FADS genotype, and mood symptoms is warranted. Aims: The present study investigated associations among dietary intake of PUFAs, the rs174575 polymorphism of the fatty acid desaturase (FADS2) gene, and psychological outcomes. The primary aim was to determine if FADS2 genotype interacts with omega-3 (n-3) and omega-6 (n-6) PUFA dietary intake to influence associations with depressive symptoms, anxiety symptoms, anger, hostility, neuroticism, or optimism. Methods: A sample of 172 female undergraduate students provided genetic material from buccal cells, and completed a food frequency questionnaire and self-report measures including the Center for Epidemiological Studies Depression Scale, PROMIS Anxiety and Anger Scales, Cook Medley Hostility Scale, NEO Neuroticism Scale, and LOT-R Optimism Scale. Results: The main finding was that higher n-3 intake was associated with greater hostility. However, n-3 intake was not related to depressive symptoms, anxiety, anger, neuroticism, or optimism, nor was n-6 intake. Further, genotype did not interact with PUFA intake for any psychological outcomes. Conclusion: This study provided no evidence that the rs174575 fatty acid desaturase polymorphism influences associations between PUFA intake and mood.
Janice Kiecolt-Glaser, PhD (Advisor)
Charles Emery, PhD (Committee Member)
Ruchika Prakash, PhD (Committee Member)
279 p.
Psychology
rs174575; FADS; PUFA; omega-3 fatty acids; polyunsaturated fatty acids; gene x environment interaction; mood; women's health

Recommended Citations

Citations

  • Hantsoo, L. (2012). Fatty Acid Desaturase (FADS) Genetic Variants and Dietary Polyunsaturated Fatty Acid Intake: Associations with Negative Affect [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1333466271

    APA Style (7th edition)

  • Hantsoo, Liisa. Fatty Acid Desaturase (FADS) Genetic Variants and Dietary Polyunsaturated Fatty Acid Intake: Associations with Negative Affect. 2012. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1333466271.

    MLA Style (8th edition)

  • Hantsoo, Liisa. "Fatty Acid Desaturase (FADS) Genetic Variants and Dietary Polyunsaturated Fatty Acid Intake: Associations with Negative Affect." Doctoral dissertation, Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1333466271

    Chicago Manual of Style (17th edition)

osu1333466271
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© 2012, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.