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Atrial Structure and Function in Non-ischemic Heart Failure

Vargas-Pinto, Pedro Alexis
http://rave.ohiolink.edu/etdc/view?acc_num=osu1353975728

Abstract Details

2012, Doctor of Philosophy, Ohio State University, Veterinary Biosciences.
For years researchers have looked for the perfect model to study heart failure (HF), and thereby understand its mechanistic causes and consequences. Among those models, there is one, rapid pacing, that has been used for decades because it recreates the process in weeks to months, as happens in human beings. Rapid pacing has answered several questions on mechanisms of cardiac remodeling during heart failure and how the body responds to it in terms of changes in hormones and proinflammatory mediators. In this study I established in a non-invasive manner the effect of time-dependent effects of heart failure on atrial depolarization time and how this is associated with atrial size and function (structural remodeling). At the in vitro level we examined the qualitative and quantitative effects of HF on atrial connexin 43. Atrial functional and structural remodeling during HF, contributes to the generation and maintenance of the most common sustained arrhythmia found in human beings, atrial fibrillation. In this study, HF caused electrophysiological remodeling (properties of the P wave), structural remodeling (LA enlargement), and dynamic functional remodeling (tardy contraction of the caudal portion of the LA). These findings closely mimic observations made in human patients at risk for atrial fibrillation.
Cynthia Carnes, PharmD,PhD (Advisor)
Robert Hamlin, DVM, PhD (Advisor)
Vadim Fedorov, PhD (Committee Member)
Sandor Gyorke, PhD (Committee Member)
Peter Mohler, PhD (Committee Member)
108 p.
Biomedical Research
tachycardia-induced Heart failure; atrial function; P wave.

Recommended Citations

Citations

  • Vargas-Pinto, P. A. (2012). Atrial Structure and Function in Non-ischemic Heart Failure [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1353975728

    APA Style (7th edition)

  • Vargas-Pinto, Pedro. Atrial Structure and Function in Non-ischemic Heart Failure. 2012. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1353975728.

    MLA Style (8th edition)

  • Vargas-Pinto, Pedro. "Atrial Structure and Function in Non-ischemic Heart Failure." Doctoral dissertation, Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1353975728

    Chicago Manual of Style (17th edition)

osu1353975728
1,079
© 2012, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.