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Catalytic Metallopeptide Promoted Inactivation of Enzyme Targets Related to Disease: Angiotensin Converting Enzyme-1 and SortaseA

Hocharoen, Lalintip
http://rave.ohiolink.edu/etdc/view?acc_num=osu1354634371

Abstract Details

2012, Doctor of Philosophy, Ohio State University, Chemistry.
The use of metal ions and complexes as tools for investigation of protein properties and interactions, as biomarkers for cellular chemistry, as well as therapeutic intervention, have emerged as major new focal points of investigation in inorganic chemistry. Early applications included the design of artificial nucleases and proteases, making use of site-selective binding to amino acid residues and metal-assisted proteolysis. However, redox active metals were also found to promote oxidative modification of amino acid side chains, including hydroxylation and carbonylation of amino acid side chains and protein cross-linking, as well as oxidative damage of nucleic acid bases and sugars, with the potential for subsequent backbone or strand cleavage, have all been observed. While many pathways to improving such modification chemistry have been explored, studies suggest that improvement of metal complex binding to the reactant molecule is an important, if not the major factor in promoting efficient chemistry. In this dissertation we present a novel application of transition metal complexes as catalytic metallodrugs to promote catalytic inactivation on protein related to disease. Herein Angiotensin Converting Enzyme-1 (ACE-1) and SortaseA (SrtA) were studied as they are involved in serious health problems.
James Cowan (Advisor)
Ross Dalbey (Committee Member)
Thomas Magliery (Committee Member)
290 p.
Chemistry
Catalytic metallopeptide; ATCUN; Angiotensin Conerting Enzyme; sortaseA

Recommended Citations

Citations

  • Hocharoen, L. (2012). Catalytic Metallopeptide Promoted Inactivation of Enzyme Targets Related to Disease: Angiotensin Converting Enzyme-1 and SortaseA [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354634371

    APA Style (7th edition)

  • Hocharoen, Lalintip. Catalytic Metallopeptide Promoted Inactivation of Enzyme Targets Related to Disease: Angiotensin Converting Enzyme-1 and SortaseA. 2012. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1354634371.

    MLA Style (8th edition)

  • Hocharoen, Lalintip. "Catalytic Metallopeptide Promoted Inactivation of Enzyme Targets Related to Disease: Angiotensin Converting Enzyme-1 and SortaseA." Doctoral dissertation, Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354634371

    Chicago Manual of Style (17th edition)

osu1354634371
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© 2012, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.