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Psychological Distress and Symptom Burden: Vulnerabilities in Chronic Lymphocytic Leukemia Patients

Morrison, Eleshia JP
http://rave.ohiolink.edu/etdc/view?acc_num=osu1366305005

Abstract Details

2013, Doctor of Philosophy, Ohio State University, Psychology.
Chronic lymphocytic leukemia is the most common adult leukemia in the U.S. (American Cancer Society, 2010). CLL is chronic and incurable. Most patients with early-stage disease do not receive treatment, but instead undergo active surveillance for disease progression. Cancer is associated with distress (Zabora et al., 2001), the risk of which is heightened in the presence of vulnerability factors (Harrison & Maguire, 1994). Distress is also associated with reporting of physical symptoms (Carr et al., 2002). This cross-sectional study examined the moderating role of vulnerability factors in the relationship between distress and physical symptom burden in a sample of untreated CLL patients (N=112). Participants were Caucasian (100%), had a mean age of 61 (range: 37-76), with the majority (62.5%) having stage 0 disease (I: 32.1%; II: 4.5%). Gender distribution was relatively even (55% male). Moderators of interest were psychiatric history (diagnosis, pharmacotherapy, psychotherapy); lack of partner status and low relationship satisfaction; low social support; and low socioeconomic status. Interaction effects were tested using multiple linear regression. Physical symptom burden and distress were bidirectionally predictive. Significant moderators were: pharmacotherapy, psychotherapy, and low social support. Post hoc analyses of social support showed that low appraisal (i.e. availability of someone with whom to discuss problems) and low belonging (i.e. availability of companionship) support were also significant moderators. These findings have implications for identifying active surveillance patients at risk for worse physical and psychological adjustment while coping with CLL.
Barbara Andersen, PhD (Advisor)
Charles Emery, PhD (Committee Member)
Robert Cudeck, PhD (Committee Member)
107 p.
Health; Psychology
Cancer; CLL; Distress; Physical Symptom Burden; Active Surveillance

Recommended Citations

Citations

  • Morrison, E. J. (2013). Psychological Distress and Symptom Burden: Vulnerabilities in Chronic Lymphocytic Leukemia Patients [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366305005

    APA Style (7th edition)

  • Morrison, Eleshia. Psychological Distress and Symptom Burden: Vulnerabilities in Chronic Lymphocytic Leukemia Patients . 2013. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1366305005.

    MLA Style (8th edition)

  • Morrison, Eleshia. "Psychological Distress and Symptom Burden: Vulnerabilities in Chronic Lymphocytic Leukemia Patients ." Doctoral dissertation, Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366305005

    Chicago Manual of Style (17th edition)

osu1366305005
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© 2013, some rights reserved.Creative Commons License Psychological Distress and Symptom Burden: Vulnerabilities in Chronic Lymphocytic Leukemia Patients by Eleshia JP Morrison is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by The Ohio State University and OhioLINK.