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Antibody/Cell Binding and Magnetic Transport in a Microfluidic Device

Adams, Shauna

Abstract Details

, Master of Science, Ohio State University, Mechanical Engineering.
The advancement of micro-total analysis systems is increasing the ability to perform multiple functions in one microfluidic device. These systems have several advantages in biomedical applications, including lower equipment and personnel costs, reduced power requirements, faster separations, and smaller sample and reagent volume requirements. Because of this, there has been a growing interest in the study of particle motion in micro and nanochannels. The Automated Cell to Biomolecule Analysis (ACBA) device labels, sorts, and analyzes cancer cells in an enriched blood sample. Understanding transport methods and the behaviour of particles in microfluidic lab-on-a-chip or micro-total analysis systems is important to the advancement of system applications. Stochastic equations are used to characterize magnetic microbead motion, and the effect of the Stokes drag force on magnetic microbeads is analyzed. Stochastic differential equations specifically the Langevin and Fokker-Planck equations are used to characterize the probability density distribution of a microbead in a microfluidic channel. The results show that due to the size of the microbead these equations the binding probability of a magnetic microbead to a circulating tumor cell. However the results do indicate that under different conditions the probability equation can be used if the Peclet number, Pe = 10 100. The capture area of a magnetic microbead with and without a cell attached to it is analyzed to see if the effect of the change of Stokes drag force on the magnetic microbead effects the magnetic capture area. It is concluded that the added drag from the attached circulating tumor cell does in fact affect the capture area of the magnetic microbead in the presence of a magnetic with a constant magnetic field.
A. T Conlisk (Advisor)
Derek Hansford (Committee Member)
Shaurya Prakash (Committee Member)

Recommended Citations

Citations

  • Adams, S. (n.d.). Antibody/Cell Binding and Magnetic Transport in a Microfluidic Device [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1372104885

    APA Style (7th edition)

  • Adams, Shauna. Antibody/Cell Binding and Magnetic Transport in a Microfluidic Device. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1372104885.

    MLA Style (8th edition)

  • Adams, Shauna. "Antibody/Cell Binding and Magnetic Transport in a Microfluidic Device." Master's thesis, Ohio State University. Accessed MARCH 28, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=osu1372104885

    Chicago Manual of Style (17th edition)