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Effects of Neuronal Nitric Oxide Synthase Signaling on Myocyte Contraction during Beta-Adrenergic Stimulation

Tang, Lifei
http://rave.ohiolink.edu/etdc/view?acc_num=osu1385336408

Abstract Details

2013, Doctor of Philosophy, Ohio State University, Biophysics.
Stimulation of the beta-adrenergic (beta-AR) pathway leads to positive inotropy, and is the major regulator of heart function. The purpose of this study is to determine how NOS1 signaling contributes to the positive inotropic effect of beta-AR stimulation. Our data suggest that during beta-AR stimulation, NOS1 is activated by Akt, which then directly activates CaMKII to increase RyR activity contributing to the positive inotropy.
Mark Ziolo (Advisor)
Sandor Gyorke (Committee Member)
Jonathan Davis (Committee Member)
Brandon Biesiedecki (Committee Member)
140 p.
Biophysics; Cellular Biology; Physiology
NOS1; CaMKII; RyR; beta Adrenergic stimulation; Akt

Recommended Citations

Citations

  • Tang, L. (2013). Effects of Neuronal Nitric Oxide Synthase Signaling on Myocyte Contraction during Beta-Adrenergic Stimulation [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385336408

    APA Style (7th edition)

  • Tang, Lifei. Effects of Neuronal Nitric Oxide Synthase Signaling on Myocyte Contraction during Beta-Adrenergic Stimulation. 2013. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1385336408.

    MLA Style (8th edition)

  • Tang, Lifei. "Effects of Neuronal Nitric Oxide Synthase Signaling on Myocyte Contraction during Beta-Adrenergic Stimulation." Doctoral dissertation, Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385336408

    Chicago Manual of Style (17th edition)

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© 2013, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.