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Dihydroartemisinin Exhibits Biologic Activity Against Canine Osteosarcoma Cell Lines

Hosoya, Kenji

Abstract Details

2007, Master of Science, Ohio State University, Veterinary Clinical Sciences.
Artemisinin is a chemical extracted from a plant Artemisia annua. It has recently been discovered to have anti-neoplastic properties. It is anecdotally being used by veterinarians and pet owners to treat various type of cancer, expecially osteosarcoma. However, evidence is lacking to support its biologic activity against canine osteosarcomas. Spontaneously occurring osteosarcoma in the dog is also an excellent large animal model for human osteosarcoma. In this study, we demonstrate the in vitro cytotoxic effect of dihydroartemisinin, a newly emerging potential anti-cancer agent with low systemic toxicity, in four canine osteosarcoma cell lines. We show that dihydroartemisinin induces concentration-dependent free radical generation by an iron-dependent mechanism, resulting in growth inhibition in all four cell lines tested. We also show that dihydroartemisinin induces cellular apoptosis and decrease of G0/G1 cell population in a concentration-dependent manner. This study is the first to demonstrate in vitro cytotoxic activity of an artemisinin derivative in canine osteosarcoma and provides relevant information in order to design a clinical trial in canine osteosarcoma.
William C. Kisseberth (Advisor)
Eric M. Green (Committee Member)
Cheryl London (Committee Member)
Guillermo Couto (Committee Member)
38 p.

Recommended Citations

Citations

  • Hosoya, K. (2007). Dihydroartemisinin Exhibits Biologic Activity Against Canine Osteosarcoma Cell Lines [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1396282245

    APA Style (7th edition)

  • Hosoya, Kenji. Dihydroartemisinin Exhibits Biologic Activity Against Canine Osteosarcoma Cell Lines. 2007. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1396282245.

    MLA Style (8th edition)

  • Hosoya, Kenji. "Dihydroartemisinin Exhibits Biologic Activity Against Canine Osteosarcoma Cell Lines." Master's thesis, Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1396282245

    Chicago Manual of Style (17th edition)