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thesis (3).pdf (620.6 KB)
ETD Abstract Container
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Theoretical Investigation of Cell Polarity Initiation in the Early C. Elegans Embryo
Author Info
Kravtsova, Natalia
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=osu1397254117
Abstract Details
Year and Degree
2014, Master of Mathematical Sciences, Ohio State University, Mathematics.
Abstract
Polarization is the process by which chemical species are unequally distributed throughout the cell creating biochemically distinct domains. In this study, mathematical modeling is used to theoretically determine what types of initial stimuli are able to initiate successful polarization. The model consist of five reaction-diffusion-advection partial differential equations for the main players in polarization process: ParA proteins (three forms), ParP proteins, and actomyosin protein complex. Equations are solved by method of lines, and data fitting is performed by linear and non-linear optimization methods (implemented in Matlab). Simulations of the model show that biochemical stimulus results in polarization of the embryo, while purely mechanical stimulus does not. In addition, regulation of actomyosin by inhibition from ParP and enhancement from ParA are studied, and it is found that inhibition from ParP plays more significant role in actomyosin regulation. Theoretical findings of this study suggest ways to direct biological experiments.
Committee
Adriana Dawes, Dr. (Advisor)
Helen Chamberlin, Dr. (Advisor)
Pages
40 p.
Subject Headings
Mathematics
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Citations
Kravtsova, N. (2014).
Theoretical Investigation of Cell Polarity Initiation in the Early C. Elegans Embryo
[Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397254117
APA Style (7th edition)
Kravtsova, Natalia.
Theoretical Investigation of Cell Polarity Initiation in the Early C. Elegans Embryo.
2014. Ohio State University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=osu1397254117.
MLA Style (8th edition)
Kravtsova, Natalia. "Theoretical Investigation of Cell Polarity Initiation in the Early C. Elegans Embryo." Master's thesis, Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397254117
Chicago Manual of Style (17th edition)
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Document number:
osu1397254117
Download Count:
989
Copyright Info
© 2014, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.