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Use of Analgesic Combination Morphine-Lidocaine-Ketamine in Holstein Calves Undergoing Ventral Midline Herniorrhaphy

Hartnack, Amanda Katherine
http://rave.ohiolink.edu/etdc/view?acc_num=osu1397824025

Abstract Details

2014, Master of Science, Ohio State University, Comparative and Veterinary Medicine.
Abdominal surgery is commonly performed in cattle for both diagnostic and therapeutic purposes. A recent survey of veterinarians in the United States revealed that abdominal surgery is thought to be the most painful of the commonly performed surgical procedures in cattle. Pain is thought to play an important role in post-operative performance in cattle undergoing abdominal surgery. However, pain evaluation in ruminants is difficult, and recent research suggests that assessment of pain in ruminants requires measurement of both physiologic and behavioral parameters. Combination analgesic techniques may be superior to individual techniques in calves following abdominal surgery. Pain and incisional algometry scores were evaluated for a total of 120 hours in calves following routine umbilical herniorrhaphy. Twenty-one calves presenting for umbilical herniorrhaphy were randomly assigned to one of two treatment groups: 1) BAN: Flunixin meglumine 1.1 mg/kg IV following intubation and at 24 hours post-op 2) MLK: Co-infusion of morphine (4.75 mcg/kg/hr), lidocaine (2.11 mg/kg/hr) and ketamine (0.42 mg/kg/hr) for 24 hours beginning immediately following intubation. Co-infusion was discontinued at 24 hours. A modified sheep pain scoring system, as well as an algometer to measure incisional pain were used by one blinded evaluator to assess comfort at 14 timepoints during the 5 day study period. There were no significant differences in heart rate, respiratory rate, or pain score between groups during the study period or during CRI administration. Incisional algometry scores were significantly different between groups during the CRI administration, with cattle in the MLK group having higher nociceptive thresholds than cattle in the BAN group(p=0.019). During the entire study period, there was not a significant difference between groups, however there was a trend towards higher thresholds in the MLK group (p=0.098). In addition to the pain scoring, blood samples were taking at 31 time points during the study period for pharmacokinetic analysis of the drugs used as well as serum cortisol analysis. Serum cortisol values were not significantly different between groups over the study period (p=0.390). However, significant differences were noted between groups during the CRI administration (p<0.001), with MLK animals having higher serum cortisol during this period than BAN animals. Additionally, time is a significant factor in cortisol concentration (p=0.001), with cortisol tending to decrease over time, and increase during periods of more intensive handling. In conclusion, we found that pain scores were similar among groups both during the CRI administration and during the entire study period, and that cortisol and incisional algometry scores were significantly different between groups during the CRI administration.
Andrew Niehaus (Advisor)
Jeffrey Lakritz (Committee Member)
Phillip Lerche (Committee Member)
Thomas Wittum (Committee Member)
71 p.
Veterinary Services
Pain Management; Abdominal Surgery Calves; Umbilical Surgery Calves; Veterinary Medicine; Continuous Rate Infusion

Recommended Citations

Citations

  • Hartnack, A. K. (2014). Use of Analgesic Combination Morphine-Lidocaine-Ketamine in Holstein Calves Undergoing Ventral Midline Herniorrhaphy [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397824025

    APA Style (7th edition)

  • Hartnack, Amanda. Use of Analgesic Combination Morphine-Lidocaine-Ketamine in Holstein Calves Undergoing Ventral Midline Herniorrhaphy. 2014. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1397824025.

    MLA Style (8th edition)

  • Hartnack, Amanda. "Use of Analgesic Combination Morphine-Lidocaine-Ketamine in Holstein Calves Undergoing Ventral Midline Herniorrhaphy." Master's thesis, Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1397824025

    Chicago Manual of Style (17th edition)

osu1397824025
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This open access ETD is published by The Ohio State University and OhioLINK.