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Validation of VO2max Assessment and Magnetic Resonance Cardiac Function Measurements Utilizing an MRI Compatible Treadmill

LaFountain, Richard A
http://rave.ohiolink.edu/etdc/view?acc_num=osu1405431417

Abstract Details

2014, Master of Science, Ohio State University, EDU Physical Activity and Educational Services.
Abstract Maximum oxygen consumption (VO2max) is considered the gold standard for assessment of cardiorespiratory fitness. Likewise, MRI is considered the gold standard for quantification of cardiac function; however, the MRI-compatible equipment required to combine these two measures has not been available to date. We utilized a specially designed MRI-compatible treadmill, and modified oxygen uptake equipment to eliminate the ferromagnetic components of the mask and headgear to perform a standard VO2max treadmill test immediately adjacent to a clinical MRI system. We sought to determine if values for a VO2max test performed in an MRI room utilizing MRI-compatible equipment were valid and accurate when compared to those obtained in an exercise lab with typical equipment set up. Ten recreationally trained subjects completed two VO2max tests to volitional fatigue in two different settings; an exercise lab and an MRI room. Oxygen and carbon dioxide were measured continuously using a computerized system. Secondary criteria were assessed to confirm maximal exercise. Resting and peak exercise images of the heart were taken before and after maximal exercise to measure global cardiac function parameters including end systolic volume (ESV), end diastolic volume (EDV), cardiac output (CO) and left ventricular ejection fraction (LVEF). VO2max values were different (P=0.033) between testing locations (47.6±8.11 vs 50.0±10.7). All subjects met or exceeded a RER =1.10 and RPE =17 at peak exercise. iii (35.6 s. ± 3.8 s.) elapsed between the end of exercise and start of imaging. At rest vs immediately following peak stress, CO was (5.1 ± 1.0 vs 16.4 ± 5.6) and LVEF was (65.2 ± 3.3 vs 78.4 ± 4.8). Simultaneous VO2max testing was completed in 7 recreationally trained healthy individuals for comparison of the inter-unit variability in two ParvoMedics TrueOne 2400 systems. Despite the equipment modifications required to measure VO2max in the MRI environment, VO2 measurements correspond to those obtained in the exercise lab. The differences in both separate and simultaneous testing produced <4-6% error, within acceptable criteria according to national certification bodies, manufacturers specifications, and previously published studies. MRI-VO2max combined testing offers potential for advanced investigation of exercise physiology and cardiopulmonary disease.
Steven Devor (Advisor)
Orlando Simonetti (Advisor)
60 p.
Kinesiology
VO2max; Cardiac Magnetic Resonance; CMR; Exercise; Treadmill; Magnetic Resonance Imaging; MRI

Recommended Citations

Citations

  • LaFountain, R. A. (2014). Validation of VO2max Assessment and Magnetic Resonance Cardiac Function Measurements Utilizing an MRI Compatible Treadmill [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1405431417

    APA Style (7th edition)

  • LaFountain, Richard. Validation of VO2max Assessment and Magnetic Resonance Cardiac Function Measurements Utilizing an MRI Compatible Treadmill. 2014. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1405431417.

    MLA Style (8th edition)

  • LaFountain, Richard. "Validation of VO2max Assessment and Magnetic Resonance Cardiac Function Measurements Utilizing an MRI Compatible Treadmill." Master's thesis, Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1405431417

    Chicago Manual of Style (17th edition)

osu1405431417
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