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Examination of a cross sectional association between intake levels of the antioxidant vitamins E, C and B6 and diabetic peripheral neuropathy

Khan, Yosef M.
http://rave.ohiolink.edu/etdc/view?acc_num=osu1407159781

Abstract Details

2005, Master of Public Health, Ohio State University, Public Health.
Background: Diabetes mellitus is a chronic disease characterized by high levels of blood glucose resulting from defects in insulin production, insulin action, or both. It is a global disease that affects all ages and races. Within the United States approximately 18.2 million people or 6.3% of the population have diabetes. It is a disease that has severe consequences and complications over time, especially if not controlled. One such complication is peripheral neuropathy, or the loss of nerve sensation and conduction. Several hypotheses have been examined in relationship to the origins and treatment of diabetic peripheral neuropathy. One such hypothesis is that antioxidant vitamin levels may have a role in both initiation and treatment of peripheral neuropathy. Objective: The objective of this analysis was to examine a cross sectional association between intake levels of the antioxidant vitamins E, C, and B6 in regards to diabetic peripheral neuropathy using data from a nationally representative survey. Methods: The aggregate of the 1999 to 2000 and 2001 to 2002 National Health and Nutrition Examination Survey were used for the data analysis. A subset of the data including only those cases with diagnosed diabetes age 40 and older was created. This data was further subset into patients whose diabetic peripheral neuropathy status was known. A logistic regression model was built with diabetic peripheral neuropathy set as the outcome variable. This was done in order to predict which set of variables, paying particular attention to the 3 antioxidant vitamins E, C, and B6, were associated with diabetic peripheral neuropathy. Results: The 1999 to 2000 NHANES dataset contains 9,280 participants and the 2000 to 2001 dataset contains 10,447. The data sets were combined to give a total of 19,757 participants. Among these participants 1,134 were both diagnosed diabetes cases and 40 years or older. The data sample used in this analysis consisted of only the diabetic patients whose peripheral neuropathy status was known. This amounted to a total of 876 patients. The main finding was that of the 3 antioxidant vitamins (vitamins E, C, and B6) thought to be associated with diabetic peripheral neuropathy treatment or prevention, only vitamin B6 was significant. Along with vitamin B6, age, marital status, insulin use, presence of retinopathy, and the interaction between insulin use and retinopathy were found to predict diabetic peripheral neuropathy. The interaction found that patients on insulin treatment along with the diagnosis of retinopathy were 3.4 times more likely to have diabetic peripheral neuropathy than patients not taking insulin nor having retinopathy. Conclusions: Five variables including age, insulin use, marital status, vitamin B6 intake, retinopathy, and the interaction between insulin use and retinopathy were found to be predictors of diabetic peripheral neuropathy. The presence of one of the three antioxidant vitamins (vitamin B6) as playing a protective role in diabetic peripheral neuropathy is noteworthy. However, further research is needed to identify whether or not antioxidant vitamins are associated with the prevention and/or treatment of diabetic peripheral neuropathy.
Amy K. Ferketich (Advisor)
Randall E. Harris (Committee Member)
64 p.
Public Health

Recommended Citations

Citations

  • Khan, Y. M. (2005). Examination of a cross sectional association between intake levels of the antioxidant vitamins E, C and B6 and diabetic peripheral neuropathy [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1407159781

    APA Style (7th edition)

  • Khan, Yosef. Examination of a cross sectional association between intake levels of the antioxidant vitamins E, C and B6 and diabetic peripheral neuropathy. 2005. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1407159781.

    MLA Style (8th edition)

  • Khan, Yosef. "Examination of a cross sectional association between intake levels of the antioxidant vitamins E, C and B6 and diabetic peripheral neuropathy." Master's thesis, Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1407159781

    Chicago Manual of Style (17th edition)

osu1407159781
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© 2005, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.