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PeterGBoyerMastersThesis082114.pdf (2.44 MB)

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A Study of Bioluminescent and Magnetic Resonance Imaging in Murine Glioblastoma Models.

Boyer, Peter Gerard
http://rave.ohiolink.edu/etdc/view?acc_num=osu1408624457

Abstract Details

2014, Master of Science, Ohio State University, Biomedical Engineering.
Bioluminescent Imaging (BLI) is an increasingly popular, non-invasive imaging modality in small animal brain tumor research. This popularity can be attributed to its low resource, high throughput imaging and its ability to detect tumor development in earlier stages than magnetic resonance imaging (MRI). However, while it does appear that BLI photon flux signals correlate with MRI derived tumor volumes, pathological events seem to cause attenuations of BLI signal. In this study, three glioblastoma tumors models were investigated using BLI, MRI and diffusion weighted imaging (DWI) in an effort to investigate the relationship between these three common imaging methods. The results from this study do demonstrate that for each tumor model there is indeed a correlation between BLI and MRI however each of these tumor models display unique growth rates, patterns and deviations which we hypothesize may be the result of unique anatomical and pathological conditions. In an effort to provide supplemental, non-invasive explanations for these pathologies, DWI was performed and while inconclusive, additional research is suggested to fully assess its potential utility for monitoring disease progression and treatment outcomes. Finally, expanding on methodologies introduced by other researchers, a multiple-modality imaging strategy is proposed with the intent to maximize each technologies strengths in characterizing and classifying brain tumor cell lines.
Kimerly Powell, Ph.D (Advisor)
Bradley Clymer, Ph.D (Committee Member)
69 p.
Biomedical Engineering
Bioluminescent Imaging; Magnetic Resonance Imaging; Diffusion weighted imaging; BLI; MRI; DWI; Glioblastoma; Brain Tumor; ADC

Recommended Citations

Citations

  • Boyer, P. G. (2014). A Study of Bioluminescent and Magnetic Resonance Imaging in Murine Glioblastoma Models. [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1408624457

    APA Style (7th edition)

  • Boyer, Peter. A Study of Bioluminescent and Magnetic Resonance Imaging in Murine Glioblastoma Models. . 2014. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1408624457.

    MLA Style (8th edition)

  • Boyer, Peter. "A Study of Bioluminescent and Magnetic Resonance Imaging in Murine Glioblastoma Models. ." Master's thesis, Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1408624457

    Chicago Manual of Style (17th edition)

osu1408624457
488
© 2014, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.