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Therapeutic suppression of mutant SOD1 by AAV9-mediated gene therapy approach in Amyotrophic Lateral Sclerosis

Likhite, Shibi B
http://rave.ohiolink.edu/etdc/view?acc_num=osu1417394084

Abstract Details

2014, Doctor of Philosophy, Ohio State University, Molecular, Cellular and Developmental Biology.
Amyotrophic Lateral Sclerosis is one of the most common, adult-onset neurodegenerative disorder, characterized by progressive and fatal loss of motor neurons in spinal cord, motor cortex and brainstem which results into muscular paralysis and ultimate respiratory failure leading to death. Here, we determined the feasibility and efficacy of post-natal downregulation of mutant SOD1 via AAV9-mediated shRNA delivery in two distinct ALS mouse models.
Brian Kaspar (Advisor)
Arthur Burghes (Committee Member)
Stephen Kolb (Committee Member)
Christine Beattie (Committee Member)
278 p.
Biology; Biomedical Research; Immunology; Molecular Biology; Neurobiology; Neurology; Neurosciences; Virology
Amyotrophic Lateral Sclerosis, ALS; Superoxide Dismutase 1, SOD1; Adeno-associated vector 9, AAV9; short hairpin RNA, shRNA; Astrocytes; Neuroinflamation; Galectin 1, Gal1; Microglia

Recommended Citations

Citations

  • Likhite, S. B. (2014). Therapeutic suppression of mutant SOD1 by AAV9-mediated gene therapy approach in Amyotrophic Lateral Sclerosis [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417394084

    APA Style (7th edition)

  • Likhite, Shibi. Therapeutic suppression of mutant SOD1 by AAV9-mediated gene therapy approach in Amyotrophic Lateral Sclerosis. 2014. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1417394084.

    MLA Style (8th edition)

  • Likhite, Shibi. "Therapeutic suppression of mutant SOD1 by AAV9-mediated gene therapy approach in Amyotrophic Lateral Sclerosis." Doctoral dissertation, Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417394084

    Chicago Manual of Style (17th edition)

osu1417394084
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© 2014, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.