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Roles of Slit-Robo Signaling in Pathogenesis of Multiple Human Diseases: HIV-1 Infection, Vascular Endothelial Inflammation and Breast Cancer

Zhao, Helong
http://rave.ohiolink.edu/etdc/view?acc_num=osu1428088097

Abstract Details

2015, Doctor of Philosophy, Ohio State University, Integrated Biomedical Science Graduate Program.
The signal molecule, Slit, is a family of secreted glycoprotein, which contains 3 isoforms, Slit1-3. The cellular surface receptor for Slit is Robo (Roundabout), which contains 4 isoforms, Robo1-4. It is now clear that, Slit and Robo are expressed and functional in a variety of tissues besides the neuronal system, including but not limited to leukocytes, endothelial cells and epithelial cells. And Slit-Robo signaling also plays important roles in regulating cell functions that are not directly related to cell migration, such as cell attachment, survival and proliferation. Thus, Slit-Robo signaling is proposed to regulate the post-development pathogenesis of multiple human diseases.
Ramesh Ganju (Advisor)
Biomedical Research

Recommended Citations

Citations

  • Zhao, H. (2015). Roles of Slit-Robo Signaling in Pathogenesis of Multiple Human Diseases: HIV-1 Infection, Vascular Endothelial Inflammation and Breast Cancer [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1428088097

    APA Style (7th edition)

  • Zhao, Helong. Roles of Slit-Robo Signaling in Pathogenesis of Multiple Human Diseases: HIV-1 Infection, Vascular Endothelial Inflammation and Breast Cancer. 2015. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1428088097.

    MLA Style (8th edition)

  • Zhao, Helong. "Roles of Slit-Robo Signaling in Pathogenesis of Multiple Human Diseases: HIV-1 Infection, Vascular Endothelial Inflammation and Breast Cancer." Doctoral dissertation, Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1428088097

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.