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Dietary Bioactives and Human Prostate Carcinogenesis

Roberts, Kristen M
http://orcid.org/0000-0001-5619-990X
http://rave.ohiolink.edu/etdc/view?acc_num=osu1429195549

Abstract Details

2015, Doctor of Philosophy, Ohio State University, OSU Nutrition.
It is estimated that dietary risk factors contribute to one in three cancers in Western nation. Prostate cancer (PCa) is associated with an affluent dietary pattern and lifestyle typical of North America and Northern Europe. Diets limited in fruits and vegetables are one characteristic of these high risk nations. Although difficult to study epidemiologically, a number of phytochemicals found in various fruits and vegetables, including berries, have been shown in laboratory studies (in vitro and with rodent models) to have anti-cancer activity. At OSU, the last decade has seen a focus upon black raspberries (BRB), a rich source of bioactive phytochemicals, and a crop of substantial importance to the state. BRB contain high concentrations of various polyphenols, of which ellagitannins and anthocyanins are best known. We propose to examine the potential of BRB to impact human PCa by fully characterizing a consistent BRB food product that is rich in phytochemicals, safe, and provides excellent compliance. We tested two novel food products (nectar and a confection) in two doses (low and high) in men with localized PCa, who have selected surgical prostatectomy as curative therapy. Various ellagitannin metabolites were measured by HPLC/MS/MS in the blood, urine, and prostate tissue. Most critically, we had three control groups (typical American diet, low polyphenol diet, and low ellagitannin diet) as no studies have thus far carefully defined by HPLC/MS/MS the background pattern/quantity of “berry derived” phytochemicals in blood, urine, and tissue. Lastly, the exploration of the vascular architecture (VA) in these men and two additional cohorts was investigated to determine the potential for VA being a biomarker for nutrition intervention studies. We have concluded from this data that our BRB food products deliver a consistent bioactive profile, are safe and have excellent compliance in a 4-week intervention trial. Quantified urolithins in the urine of the men was consistent with baseline diet ellagitannin intake and the dose of the BRB food product. Lastly, utilizing the vascular architecture as a biomarker for nutrition intervention studies is still in its infancy. Measurement of the vascular architecture is dependent upon the aggressiveness of the PCa, the endothelial cell marker used to identify the blood vessels and the technology used to analyze the architecture.
Steven Clinton (Advisor)
189 p.
Nutrition

Recommended Citations

Citations

  • Roberts, K. M. (2015). Dietary Bioactives and Human Prostate Carcinogenesis [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429195549

    APA Style (7th edition)

  • Roberts, Kristen. Dietary Bioactives and Human Prostate Carcinogenesis. 2015. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1429195549.

    MLA Style (8th edition)

  • Roberts, Kristen. "Dietary Bioactives and Human Prostate Carcinogenesis." Doctoral dissertation, Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429195549

    Chicago Manual of Style (17th edition)

osu1429195549
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© 2015, some rights reserved.Creative Commons License Dietary Bioactives and Human Prostate Carcinogenesis by Kristen M Roberts is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by The Ohio State University and OhioLINK.