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Flashing Light-Evoked Pupil Responses in Subjects with Glaucoma or Traumatic Brain Injury

Shorter, Patrick D
http://orcid.org/0000-0002-1251-4637
http://rave.ohiolink.edu/etdc/view?acc_num=osu1429622042

Abstract Details

2015, Doctor of Philosophy, Ohio State University, Vision Science.
Intrinsically photosensitive retinal ganglion cells (ipRGCs) are the primary conduits for retinal signals influencing the pupil response to light. Measuring pupil responses to light of different intensities, spectral compositions, and spatial features allows an indirect measure of ipRGC activity. I observed that pupil constriction changes over time in response to alternating red/blue flashing light stimuli, an effect termed `photopotentiation’. I showed that exposure to long wavelength red light is capable of photopotentiating the pupil response to subsequent light exposures, and this effect persists through 5 minutes of dark adaptation. The goal of this work was to examine whether this adaptive pupillary response is altered in individuals with glaucoma (GLC) and in individuals with persistent photosensitivity after mild traumatic brain injury (PS-TBI). Both GLC and PS-TBI groups showed deficits in pupil responses to the tests involving flickering, alternating red and blue light. GLC subjects were deficient in the ability of their pupil to photopotentiate to red light, leading to a less constricted pupil than controls over the course of the test. The pupil responses of PS-TBI subjects were affected by the amount of dark adaptation preceding the test, and were more sensitive in a light adapted state. The 2 minute test of alternating red and blue light used in this study may have utility as an objective screening tool in both GLC and PS-TBI, and should be investigated for use in other applications, including other retinal diseases (e.g. AMD), alertness and fatigue management, and circadian rhythm studies.
Andrew Hartwick, Dr. (Advisor)
Laura Barnes, Dr. (Committee Member)
Heather Chandler, Dr. (Committee Member)
Donald Mutti, Dr. (Committee Member)
Dean VanNasdale, Dr. (Committee Member)
150 p.
Medicine; Neurosciences; Ophthalmology; Optics
pupil, glaucoma, traumatic brain injury, photosensitivity, ipRGC, melanopsin, photopotentiation, pupillometry, retina adaptation

Recommended Citations

Citations

  • Shorter, P. D. (2015). Flashing Light-Evoked Pupil Responses in Subjects with Glaucoma or Traumatic Brain Injury [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429622042

    APA Style (7th edition)

  • Shorter, Patrick. Flashing Light-Evoked Pupil Responses in Subjects with Glaucoma or Traumatic Brain Injury. 2015. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1429622042.

    MLA Style (8th edition)

  • Shorter, Patrick. "Flashing Light-Evoked Pupil Responses in Subjects with Glaucoma or Traumatic Brain Injury." Doctoral dissertation, Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429622042

    Chicago Manual of Style (17th edition)

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© 2015, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.