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Control of Dynamic DNA Origami Mechanisms Using Integrated Functional Components

Miller, Carl A
http://orcid.org/0000-0003-2252-6970
http://rave.ohiolink.edu/etdc/view?acc_num=osu1429812012

Abstract Details

2015, Master of Science, Ohio State University, Mechanical Engineering.
Scaffolded DNA origami has been used to construct objects with complex three-dimensional geometries via molecular self-assembly to create functional nanoscale devices in the 10-100 nm size range. The production of static DNA origami structures is well documented. Only a few designed DNA nanostructures utilize structural dynamics to achieve functionality. In contrast, there has been an emergence of work showing the functionalization of DNA nanostructures through the incorporation of functional molecules or nanoparticles. This work expands the scope of DNA origami applications by incorporating dynamic functional molecules to control dynamic components of DNA origami structures. An in depth investigation into controlling the dynamic motion of a DNA origami hinge through the integration of a transcription repressor protein is the main focus of this thesis. Investigation into the attachment of other nanoscale functional molecules to enable control over nanoscale DNA origami designs is also performed as a proof of concept. This work sets a foundation to create useful dynamic tools to explore complex nanoscale systems.
Carlos Castro, Dr. (Advisor)
Michael Poirier, Dr. (Committee Member)
Jonathan Song, Dr. (Committee Member)
135 p.
Biomedical Engineering; Engineering; Mechanical Engineering; Mechanics
DNA origami, DNA nanotechnology, LexA, magnetic quantum dots, dynamics, nanotechnology, nanoengineering, biodesign, self assembly,

Recommended Citations

Citations

  • Miller, C. A. (2015). Control of Dynamic DNA Origami Mechanisms Using Integrated Functional Components [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429812012

    APA Style (7th edition)

  • Miller, Carl. Control of Dynamic DNA Origami Mechanisms Using Integrated Functional Components. 2015. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1429812012.

    MLA Style (8th edition)

  • Miller, Carl. "Control of Dynamic DNA Origami Mechanisms Using Integrated Functional Components." Master's thesis, Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1429812012

    Chicago Manual of Style (17th edition)

osu1429812012
1,074
© 2015, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.