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A comparison of liposomal bupivacaine and bupivacaine for pain control in untreated symptomatic vital teeth

Bultema, Kristy
http://rave.ohiolink.edu/etdc/view?acc_num=osu1437169789

Abstract Details

2015, Master of Science, Ohio State University, Dentistry.
Studies from medical literature have demonstrated prolonged pain relief and reduction in opioid utilization for up to 72 hours postoperatively in patients that received post-surgical infiltration injections with liposomal bupivacaine. At the present time, there are no studies in dental literature that have investigated liposomal bupivacaine for pain control in endodontics. The purpose of this double-blind, randomized controlled trial was to compare bupivacaine HCl to liposomal bupivacaine for endodontic pain control in untreated symptomatic vital posterior teeth in patients experiencing moderate to severe pain. One hundred adult patients were randomly divided into two groups and received either 4 mL of liposomal bupivacaine (13.3 mg/mL) or 4 mL of 0.5% bupivacaine HCl with 1:200,000 epinephrine by infiltration following injection with 1.8 mL of 2% lidocaine with 1:100,000 epinephrine via infiltration or inferior alveolar nerve block. Patients received a diary for the day of the appointment (day 0) and three days post-injection to record tooth numbness, lip numbness, pain levels and analgesics (non-narcotic and narcotic) utilization. No significant differences were found between treatment groups for tooth numbness, pain, use of non-narcotic and narcotic pain medications. A statistically significant difference in lip numbness was found on day 1 to day 3 for the liposomal bupivacaine group. In conclusion, liposomal bupivacaine did not provide prolonged pain control, nor did it reduce analgesic consumption when used for untreated posterior symptomatic vital teeth.
Sara Fowler, DMD, MS (Advisor)
Melissa Drum, DDS, MS (Committee Member)
John Nusstein, DDS, MS (Committee Member)
Al Reader, DDS, MS (Committee Member)
F. Michael Beck, DDS, MA (Committee Member)
125 p.
Dentistry
liposomal bupivacaine; bupivacaine HCl; pain control; pain; tooth; teeth; numbness; anesthesia; anesthetic; symptomatic; irreversible pulpitis; symptomatic vital teeth; untreated; endodontics; vital

Recommended Citations

Citations

  • Bultema, K. (2015). A comparison of liposomal bupivacaine and bupivacaine for pain control in untreated symptomatic vital teeth [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437169789

    APA Style (7th edition)

  • Bultema, Kristy. A comparison of liposomal bupivacaine and bupivacaine for pain control in untreated symptomatic vital teeth. 2015. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1437169789.

    MLA Style (8th edition)

  • Bultema, Kristy. "A comparison of liposomal bupivacaine and bupivacaine for pain control in untreated symptomatic vital teeth." Master's thesis, Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437169789

    Chicago Manual of Style (17th edition)

osu1437169789
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This open access ETD is published by The Ohio State University and OhioLINK.