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KLN- Masters Thesis.pdf (141.53 MB)

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Self-Assembly, Characterization, and Cytotoxicity Studies of a Camptothecin-Dipeptide Library

Neidrich, Keisha L
http://rave.ohiolink.edu/etdc/view?acc_num=osu1452178852

Abstract Details

2016, Master of Science, Ohio State University, Chemistry.
Nanoscience is the study of scientific manipulations that occur between 1 nM and 1 µM. This vignette of science opens the doors to novel methodologies with which to solve some of the most challenging obstacles currently facing science. Study at this level has created nanomaterials, which can be assembled in an assortment of ways. Perhaps one of the most common is self-assembly, in which singular molecules will order themselves into three dimensional structures based on their intermolecular interactions. Peptides are commonly used as building blocks for these assemblies due to their availability, convenient synthesis, and biocompatibility. These self-assembling nanomaterials can lead to “materials by design”, giving the researcher complete control over the size, properties, and overall chemistry of the structure. One way in which these materials have been applied is through the encapsulation of hydrophobic chemotherapeutics. Through this encapsulation, hydrophobic drugs that experience instability in water can be not only protected, but better solubility as well. One example of this class of drugs is camptothecin, a highly effective drug in vitro that results in a high toxicity in vivo due to a reversible ring opening. By protecting this drug, not only can its effectiveness be retained, but its solubility in vivo can be improved dramatically. In this study, we have provided a library of dipeptide-camptothecin molecules that self-assemble into three-dimensional nanostructures. The library was accomplished across sixty-six different compounds; containing 11 different amino acids in 6 different configurations. An additional study was completed in order to determine the effect of oxidation or reduction on a cysteine based camptothecin-nanostructure. These studies have demonstrated that a wide variety of peptides will self-assemble, as well as trends in their zeta potential and cytotoxicity, and environmental effects.
Jon Parquette (Advisor)
Jovica Badjic (Committee Member)
346 p.
Biology; Chemistry; Nanoscience; Nanotechnology
Self-assembly; Peptide Amphiphiles; Camptothecin; Drug Delivery; Nanostructures; Nanoscience; Peptide Library

Recommended Citations

Citations

  • Neidrich, K. L. (2016). Self-Assembly, Characterization, and Cytotoxicity Studies of a Camptothecin-Dipeptide Library [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1452178852

    APA Style (7th edition)

  • Neidrich, Keisha. Self-Assembly, Characterization, and Cytotoxicity Studies of a Camptothecin-Dipeptide Library. 2016. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1452178852.

    MLA Style (8th edition)

  • Neidrich, Keisha. "Self-Assembly, Characterization, and Cytotoxicity Studies of a Camptothecin-Dipeptide Library." Master's thesis, Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1452178852

    Chicago Manual of Style (17th edition)

osu1452178852
435
© 2016, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.