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An NF-kappaB - EphrinA5 - Dependent Communication between NG2+ Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates

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2016, Doctor of Philosophy, Ohio State University, Molecular, Cellular and Developmental Biology.
Skeletal muscle growth immediately following birth is a critical stage of development needed for proper body posture and locomotion. However, compared to embryogenesis and adulthood, the processes regulating the maturation of neonatal muscles is considerably less clear. Studies in the 1960s had predicted that muscle growth results from nuclear accretion of myoblasts preferentially at the tips of immature myofibers. Remarkably, since that time, little information has been added to resolve how myoblasts migrate to the ends of a fiber for nuclear accretion to occur. Here, we provide insight to this process by revealing a unique NF-kappaB dependent communication between NG2+ interstitial cells and myoblasts. NF-kappaB is active in NG2+ cells to promote myoblasts migration through cell-cell contact to the tips of growing myofibers. This occurs through expression of ephrinA5 from NG2+ cells, which we further deduce is an NF-kappaB target gene. Together, results suggest that NF-kappaB plays an important role in the development of newborn muscles to ensure proper myoblast migration for fiber growth.
Denis Guttridge, PhD (Advisor)
Samir Ghadiali, PhD (Committee Member)
Joy Lincoln, PhD (Committee Member)
Amanda Simcox, PhD (Committee Member)
106 p.

Recommended Citations

Citations

  • Gu, J. (2016). An NF-kappaB - EphrinA5 - Dependent Communication between NG2+ Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1458152802

    APA Style (7th edition)

  • Gu, Jinmo. An NF-kappaB - EphrinA5 - Dependent Communication between NG2+ Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates. 2016. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1458152802.

    MLA Style (8th edition)

  • Gu, Jinmo. "An NF-kappaB - EphrinA5 - Dependent Communication between NG2+ Interstitial Cells and Myoblasts Promotes Muscle Growth in Neonates." Doctoral dissertation, Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1458152802

    Chicago Manual of Style (17th edition)