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Premature Infants with Myopic Eyes

Morrison, Ann Marie
http://rave.ohiolink.edu/etdc/view?acc_num=osu1460038664

Abstract Details

2016, Master of Science, Ohio State University, Vision Science.
Purpose: To compare the ocular structural differences between myopic school-aged children born with a history of retinopathy of prematurity and full term children and infants. Methods: Three subjects aged 10, 11, and 7 participated in the present case series. Cycloplegic central and peripheral refractive error were obtained with the Grand Seiko WR 5100-K Autorefractor. Axial length was obtained with the Zeiss IOL-Master 500 and the Humphrey Model 820 ultrasonograph. Crystalline lens power, curvature, and thickness was measured with a custom made phakometer that recorded Purkinje images produced by a pair of fiber optic white light sources. Crystalline lens radii of curvature, power, and refractive index were calculated using custom algorithms. The biometric data from our subjects were compared to data from both the Berkeley Infant Biometry Study (BIBS) and Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) study to draw structural comparisons to infants and full-term school aged children. Results: Equations were derived from the BIBS data set to calculate age equivalent calculations for crystalline lens thickness, anterior and posterior lens radius, calculated lens power, and refractive index. All subjects had anterior and posterior lens radii that were equivalent to infants. One subject had a lens thickness comparable to an infant in utero and another had a lens thicker than all infants in BIBS. The third subject had a lens thickness that was not infantile was much younger than the subject’s actual age. The age equivalents for calculated lens power were not as immature as other measurements but the calculated equivalent ages were much younger than all of our subjects’ true age. The refractive indices were too low to provide age equivalent calculations from the BIBS data, suggesting refractive index is more childlike than infantile. Predictive outcome measures were calculated for other ocular parameters using equations from the CLEERE study. These equations were constructed for axial length, crystalline lens thickness, calculated lens power, anterior and posterior lens radius of curvature, refractive index, and relative peripheral refractive error. The predictive outcomes were calculated as a function of age, gender, and refractive error. Two of the three subjects have axial lengths that were shorter than expected while the third subject had an axial length comparable to a full term counterpart. All of our subjects had thicker and steeper crystalline lenses than would be expected for a person of the same age, gender, and refractive error. Two of the three subjects had stronger crystalline lenses than would be expected and the third subject had a crystalline lens slightly less powerful than a full term counterpart. There were not any considerable differences in refractive index between our subjects and predicted measurements. Our findings for relative peripheral refractive error were generally more myopic than full term counterparts. Conclusions: There are considerable differences in the ocular structures of myopic children with a history of prematurity compared to those born full term. Crystalline lens parameters in this premature population appear to be more infantile than their full term counterparts. In general, premature subjects have crystalline lenses that appear underdeveloped, more powerful, and steeper than their full term, myopic, counterparts and their eyes appear shorter and more oblate.
Donald Mutti, OD, PhD (Advisor)
Jeffrey Walline, OD, PhD (Committee Member)
Michael Earley, OD, PhD (Committee Member)
78 p.
Ophthalmology; Optics

Recommended Citations

Citations

  • Morrison, A. M. (2016). Premature Infants with Myopic Eyes [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460038664

    APA Style (7th edition)

  • Morrison, Ann. Premature Infants with Myopic Eyes. 2016. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1460038664.

    MLA Style (8th edition)

  • Morrison, Ann. "Premature Infants with Myopic Eyes." Master's thesis, Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460038664

    Chicago Manual of Style (17th edition)

osu1460038664
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This open access ETD is published by The Ohio State University and OhioLINK.