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Antimicrobial Use and Resistance in Zoonotic Bacteria Recovered from Nonhuman Primates

Kim, Jeffrey
http://rave.ohiolink.edu/etdc/view?acc_num=osu1460912847

Abstract Details

2016, Master of Public Health, Ohio State University, Public Health.
Antimicrobial resistance (AMR) has become a central topic as it is a growing threat in human and animal health. Major surveillance systems, such as the National Antimicrobial Resistance Monitoring System (NARMS), are now established to monitor AMR and provide physicians, veterinarians, and scientists with valuable information to make informed decisions on policy and therapeutic treatment. However, there is a lack of comprehensive literature on AMR among nonhuman primates (NHP). This study aims to provide data on current antimicrobial use strategies and on the prevalence of AMR in zoonotic bacteria recovered from NHPs within biomedical research institutions. We focused on four zoonotic enteric bacteria: Shigella flexneri, Yersinia enterocolitica, Y. pseudotuberculosis, and Campylobacter jejuni. Fifteen veterinarians, seven biomedical research institutions, and four diagnostic laboratories participated, providing susceptibility test results across three years (1/2012 – 4/2015). Veterinarians primarily treated cases caused by S. flexneri, Y. enterocolitica, and Y. pseudotuberculosis with enrofloxacin, but treated C. jejuni cases with azithromycin and tylosin. All isolates were susceptible to their associated primary antimicrobials. However, high proportions of AMR was observed to other antimicrobials. S flexneri isolates were resistant to erythromycin (87.5%, 21/24), doxycycline (73.7%, 14/19), and tetracycline (38.2%, 157/411). Y. enterocolitica isolates were resistant to ampicillin (100%, 49/49) and cefazolin (93.6%, 44/47). No Y. pseudotuberculosis isolate (0/58) was resistant to any tested antimicrobial. C. jejuni isolates were resistant to methicillin (99.5%, 569/572) and cephalothin (97.5%, 557/571). Notably, resistance patterns were not shared between this study’s NHP isolates and human isolates presented by NARMS. This study demonstrates that zoonotic bacteria recovered from NHP diagnostic samples are broadly susceptible to the antimicrobials used to treat the clinical infections. These results can help veterinarians ensure effective antimicrobial therapy and protect staff by minimizing occupational risk.
Gregory Habing (Advisor)
Dondrae Coble (Committee Member)
Julie Bower (Committee Member)
102 p.
Animal Diseases; Animal Sciences; Animals; Biomedical Research; Occupational Health; Occupational Safety; Public Health; Veterinary Services
Antimicrobial resistance; antibiotic resistance; shigella flexneri; yersinia enterocolitica; yersinia pseudotuberculosis; campylobacter jejuni; nonhuman primate; public health; occupational risk; macrolide; fluoroquinolone;

Recommended Citations

Citations

  • Kim, J. (2016). Antimicrobial Use and Resistance in Zoonotic Bacteria Recovered from Nonhuman Primates [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460912847

    APA Style (7th edition)

  • Kim, Jeffrey. Antimicrobial Use and Resistance in Zoonotic Bacteria Recovered from Nonhuman Primates. 2016. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1460912847.

    MLA Style (8th edition)

  • Kim, Jeffrey. "Antimicrobial Use and Resistance in Zoonotic Bacteria Recovered from Nonhuman Primates." Master's thesis, Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460912847

    Chicago Manual of Style (17th edition)

osu1460912847
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This open access ETD is published by The Ohio State University and OhioLINK.