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Development and testing of a dietary intervention to enhance diet quality and improve inflammation in post menopausal women.pdf (1.85 MB)
ETD Abstract Container
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Development and Testing of a Dietary Intervention to Enhance Diet Quality and Improve Inflammation in Postmenopausal Women
Author Info
Arnold, Kristen Karin
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=osu1461082703
Abstract Details
Year and Degree
2016, Master of Science, Ohio State University, Human Ecology: Human Nutrition.
Abstract
Background: The two leading causes of death of women in the United States, cardiovascular disease and cancer, are associated with elevated chronic inflammatory markers. There is a critical need to develop therapies which are safe and efficacious in order to lower chronic inflammation and improve health outcomes in women, specifically obese postmenopausal women, a group particularly vulnerable to chronic inflammation. Methods: This pilot study was a single-arm experimental pre-post test design, that tested the efficacy of the LAS-03 (low added sugar, high fiber, and omega-3 fatty acids) intervention to improve overall diet quality and lower inflammation in obese postmenopausal women. LAS-03 was delivered by a registered dietitian via in-person and phone-based counseling over 12 weeks. Self-reported dietary intake over the previous 3 months was assessed using electronic Food Frequency Questionnaires. Primary outcome measures included self-reported dietary intake of dietary components emphasized in the intervention, diet quality as measured by the HEI 2010, and biomarkers of inflammation as measured by serum inflammatory cytokines (tumor necrosis factor a receptor-2 (TNFaR-II), interleukin-6 (IL-6), high sensitivity C-reactive protein (hsCRP)). Urinary excretion of sucrose, a biomarker of dietary intake of added sugars, was measured for validation purposes. Results: Self-reported dietary intake improved for added sugar, sucrose, sweet servings, fatty fish, and omega-3 fatty acids DHA and EPA (all p<0.05). There was also a significant increase in calculated total HEI 2010 scores as well as HEI 2010 subgroup scores: vegetables, greens and beans, seafoods and plant proteins, fatty acids, empty calories (p<0.05). Mean inflammatory markers all trended downwards and TNFaR-II significantly decreased pre-post intervention (p<0.05). There were significant correlations between fasting spot urinary sucrose excretion (g/L creatinine) and self-reported 24-hour dietary intake of added sugars at post intervention (rs=0.70, p=0.006). Conclusions: This pilot study demonstrated the potential efficacy of a dietary intervention in obese postmenopausal women to improve overall diet quality and serum inflammatory markers. Urinary sucrose excretion was an objective biomarker for dietary added sugar intake in this sample of women; further research is needed to validate this method.
Committee
Tonya Orchard (Advisor)
Rebecca Andridge (Committee Member)
Julie Kennel (Committee Member)
Carolyn Gunther (Committee Member)
Pages
95 p.
Subject Headings
Biology
;
Health
;
Health Sciences
;
Nutrition
Keywords
postmenopause
;
diet quality
;
inflammation
;
biomarker
;
nutrition
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Refworks
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Mendeley
Citations
Arnold, K. K. (2016).
Development and Testing of a Dietary Intervention to Enhance Diet Quality and Improve Inflammation in Postmenopausal Women
[Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461082703
APA Style (7th edition)
Arnold, Kristen.
Development and Testing of a Dietary Intervention to Enhance Diet Quality and Improve Inflammation in Postmenopausal Women.
2016. Ohio State University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=osu1461082703.
MLA Style (8th edition)
Arnold, Kristen. "Development and Testing of a Dietary Intervention to Enhance Diet Quality and Improve Inflammation in Postmenopausal Women." Master's thesis, Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461082703
Chicago Manual of Style (17th edition)
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Document number:
osu1461082703
Download Count:
467
Copyright Info
© 2016, some rights reserved.
Development and Testing of a Dietary Intervention to Enhance Diet Quality and Improve Inflammation in Postmenopausal Women by Kristen Karin Arnold is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by The Ohio State University and OhioLINK.