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Modelling Differences in MCP-1 Levels During Early Tuberculosis Infection in Diabetics

Henry, John Michael
http://rave.ohiolink.edu/etdc/view?acc_num=osu1461312609

Abstract Details

2016, Master of Mathematical Sciences, Ohio State University, Mathematical Sciences.
Patients with chronic inflammatory diseases such as Type II Diabetes Mellitus (T2DM) have an increased susceptibility to developing infections, although the exact underlying mechanisms are poorly understood. Tuberculosis (TB) infection is of particular concern; TB is the top bacterial killer in the world and TB/T2DM comorbidity is complicating any intervention strategies. One big difference in patients with both TB and T2DM is an increased switching time, that is the time between the initial infection and the switching of macrophage composition in the lungs from mostly type 2 macrophages to mostly type 1 macrophages. This switch is vital to help patients combat the infection more efficiently and prime the adaptive immune response. Because recruitment plays a large role in this process, we focused on modeling differences in MCP-1 concentration in TB patients with and without T2DM. We built a two compartment system of ordinary differential equations to describe the concentrations of macrophages, bacteria, and key cytokines in both the lungs and peripheral blood. We found through our simulations that the MCP-1 gradient between the lungs and the peripheral blood in patients with both conditions was lower than in non-diabetic TB patients, which would lead to a decreased rate of cell recruitment to the infection site. Therefore MCP-1 may be a molecule of interest as a therapeutic target in future studies.
Avner Friedman, Dr. (Advisor)
Larry Schlesinger, Dr. (Committee Member)
37 p.
Mathematics

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Citations

  • Henry, J. M. (2016). Modelling Differences in MCP-1 Levels During Early Tuberculosis Infection in Diabetics [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461312609

    APA Style (7th edition)

  • Henry, John. Modelling Differences in MCP-1 Levels During Early Tuberculosis Infection in Diabetics. 2016. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1461312609.

    MLA Style (8th edition)

  • Henry, John. "Modelling Differences in MCP-1 Levels During Early Tuberculosis Infection in Diabetics." Master's thesis, Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461312609

    Chicago Manual of Style (17th edition)

osu1461312609
368
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This open access ETD is published by The Ohio State University and OhioLINK.