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ETD Abstract Container

Abstract Header

Visualization and Integrative analysis of cancer multi-omics data

Ding, Hao
http://orcid.org/0000-0001-5098-8473
http://rave.ohiolink.edu/etdc/view?acc_num=osu1467843712

Abstract Details

2016, Doctor of Philosophy, Ohio State University, Computer Science and Engineering.
Understanding and characterizing cancer heterogeneity not only generates new mechanistic insights but can also lead to personalized treatments for patients. With advances in data generation technologies, ever-increasing amounts and types of multi-omics open great opportunities for researchers to gain extremely valuable information for cancer research and clinical biomarker discovery. However, the vast and complex nature of multi-omics data pose significant challenges regarding the extraction of useful information and the effective integration of multiple types of data. This dissertation tackles the problem of multi-omics data analysis through both visual analytics and computational angles. First, we present GRAPh based Histology Image Explorer (GRAPHIE), a visual analytics tool designed to explore, annotate, and discover potential relationships in phenomics datasets (histology images). By taking a data-driven approach, we developed an unbiased way to visualize the entire dataset with node-link graphs. The intuitive visualization and rich set of interactive functions allow users to effectively explore the dataset. While (GRAPHIE) focusing on analysising the histological information, we present the second visual analytics tool, integrative Genomic Patient Stratification explorer (iGPSe) which leverages multiple types of molecular features to further characterize patients and tumors. iGPSe is designed to assist researchers in effectively performing integrative multi-omics analysis through interactive visualization components. The tool integrates unsupervised clustering with graph and parallel sets visualization and allows a direct comparison of clinical outcomes via survival analysis. For both tools, we comprehensively analyzed the design requirements and carried out users' case studies to demonstrated the usefulness. Lastly, we developed a computational method that can jointly cluster cancer patient samples based on multi-omics data. The proposed method creates a patient-to-patient similarity graph for each data type as an intermediate representation of each omics data type and merges the graphs through subspace analysis on a Grassmann manifold. We applied our approach to a breast cancer dataset and showed that by integrating gene expression, microRNA, and DNA methylation data, the proposed method would produce potentially clinically useful subtypes of breast cancer. The proposed visual analytics tools and computational method can be extended to more generalized applications in which exploration and integration of multi-omics data are needed. This dissertation also provides high-level design considerations for visual analytics tools to conceptual methodologies in integrative analysis to future researchers and practitioners for devising effective multi-omics data analysis.
Raghu Machiraju (Advisor)
Huang Kun (Advisor)
Mathe Ewy (Committee Member)
150 p.
Bioinformatics; Computer Science

Recommended Citations

Citations

  • Ding, H. (2016). Visualization and Integrative analysis of cancer multi-omics data [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1467843712

    APA Style (7th edition)

  • Ding, Hao. Visualization and Integrative analysis of cancer multi-omics data. 2016. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1467843712.

    MLA Style (8th edition)

  • Ding, Hao. "Visualization and Integrative analysis of cancer multi-omics data." Doctoral dissertation, Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1467843712

    Chicago Manual of Style (17th edition)

osu1467843712
2,298
© 2016, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.