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Stability of the Oral Microbiome in Children - A Six Month Longitudinal Study

Iyer, Priyanka
http://rave.ohiolink.edu/etdc/view?acc_num=osu1469201519

Abstract Details

2016, Master of Science, Ohio State University, Dentistry.
Introduction: The human oral cavity is home to approximately 700 different species of bacteria that are often represented by multiple strains, and each person harbors a unique subset of these. The microbial community differs between childhood and adulthood; however, it is unclear whether species once acquired are retained or for how long they remain as children accumulate exposures to new species. Purpose: The purpose of this study is to investigate the stability of the oral microbial community at the level of species in children from age 1-13 years, over a six-month period. Materials and Methods: Salivary, supragingival and subgingival plaque samples were collected from children, and then resampled after six months. Bacterial profiles at the species level were compared for the two time points among different age cohorts. Amplification and sequencing of the ribosomal operon 16S rRNA gene was used for species identification. Results: Based on data analyzed from 43 subjects, results indicate measurable stability of the oral microbiome at the level of species over a six-month period in children. This stability was observed in all sampling sites – salivary, supragingival, and subgingival. Future studies will continue to re-sample these patients at six month intervals to confirm our findings. Additionally, the stability of the oral microbiome at the level of strains should also be examined.
Ann Griffen, DDS, MS (Advisor)
Eugene Leys, PhD (Committee Member)
Erin Gross, DDS, MS, PhD (Committee Member)
21 p.
Dentistry; Health Care; Microbiology
oral microbiome stability chilren longitudinal

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Citations

  • Iyer, P. (2016). Stability of the Oral Microbiome in Children - A Six Month Longitudinal Study [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1469201519

    APA Style (7th edition)

  • Iyer, Priyanka. Stability of the Oral Microbiome in Children - A Six Month Longitudinal Study. 2016. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1469201519.

    MLA Style (8th edition)

  • Iyer, Priyanka. "Stability of the Oral Microbiome in Children - A Six Month Longitudinal Study." Master's thesis, Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1469201519

    Chicago Manual of Style (17th edition)

osu1469201519
380
© 2016, some rights reserved.Creative Commons License Stability of the Oral Microbiome in Children - A Six Month Longitudinal Study by Priyanka Iyer is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by The Ohio State University and OhioLINK.