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Jennifer Song Thesis.pdf (927.95 KB)

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Evaluation of Parathyroid Hormone and Preoperative Vitamin D as Predictive Factors for Post-operative Hypocalcemia in Dogs with Primary Hyperparathyroidism.

Song, Jennifer
http://rave.ohiolink.edu/etdc/view?acc_num=osu1469451016

Abstract Details

2016, Master of Science, Ohio State University, Comparative and Veterinary Medicine.
Primary hyperparathyroidism (PHPTH) results in excessive secretion of parathyroid hormone (PTH) causing hypercalcemia. Vitamin D also contributes to calcium regulation. People with PHPTH and vitamin D deficiency have more severe disease as seen with higher preoperative calcium and longer duration of postoperative hypocalcemia. In people and dogs, a decrease of more than 50% of intraoperative PTH concentration 10 minutes after parathyroidectomy is associated with complete surgical resection of the autonomously functioning gland. Post-operative hypocalcemia after parathyroidectomy necessitates immediate medical intervention and prolonged hospitalization. Distinct pre-operative predictors of postoperative hypocalcemia have not been identified in veterinary medicine. The objective of this study was to prospectively monitor the trends in PTH concentrations and vitamin D metabolites and determine predictive factors for the development of postoperative hypocalcemia. Our hypothesis was that dogs with a greater than 75% percent change between baseline and intraoperative PTH concentrations will be more likely to develop hypocalcemia in the immediate post-operative period. A second hypothesis is that dogs with low vitamin D status will be more likely to develop postoperative hypocalcemia. Dogs that developed postoperative hypocalcemia had a significantly larger decrease in PTH concentration than dogs that remained normocalcemic (p<0.008). All dogs had low preoperative calcidiol concentration. This is the first prospective study examining vitamin D and preoperative factors in dogs with PHPTH as predictors of postoperative hypocalcemia.
Kathleen Ham, DVM, MS, DACVS (Advisor)
Dennis Chew, DVM, MS, DACVIM (Committee Member)
Chen Gilor, DVM, PhD, DACVIM (Committee Member)
85 p.
Animal Sciences; Animals; Endocrinology; Medicine; Veterinary Services
Primary hyperparathyroid, hypocalcemia, parathyroid hormone, dogs

Recommended Citations

Citations

  • Song, J. (2016). Evaluation of Parathyroid Hormone and Preoperative Vitamin D as Predictive Factors for Post-operative Hypocalcemia in Dogs with Primary Hyperparathyroidism. [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1469451016

    APA Style (7th edition)

  • Song, Jennifer. Evaluation of Parathyroid Hormone and Preoperative Vitamin D as Predictive Factors for Post-operative Hypocalcemia in Dogs with Primary Hyperparathyroidism. 2016. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1469451016.

    MLA Style (8th edition)

  • Song, Jennifer. "Evaluation of Parathyroid Hormone and Preoperative Vitamin D as Predictive Factors for Post-operative Hypocalcemia in Dogs with Primary Hyperparathyroidism." Master's thesis, Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1469451016

    Chicago Manual of Style (17th edition)

osu1469451016
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© 2016, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.