Skip to Main Content
 

Global Search Box

 
 
 
 

ETD Abstract Container

Abstract Header

The effect of diet and adiposity on the secretion of incretin hormones in cats

McCool, Katherine E

Abstract Details

2016, Master of Science, Ohio State University, Comparative and Veterinary Medicine.
Degree of adiposity and dietary macronutrient composition affect the secretion of incretin hormones but little is known about their effect in cats. In this study, 7 overweight cats were fed a maintenance diet (MD) for 2 weeks followed by a restricted calorie control diet (RCD, lower fat, higher in carbohydrates and fiber). Cats were fed ad-libitum initially and then food was restricted to achieve 1-2% loss of body weight weekly (11 weeks). When lean, cats were fed MD for 2 additional weeks. A standardized meal test (SMT) using a third diet was performed after at least 7 days on each diet, before and after weight loss (4 SMT’s total). Glucose, insulin, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) concentrations were measured immediately before and over 6 hours after feeding the SMT. Area under the concentrations curve (AUC) was compared for GLP-1, GIP, and insulin using linear regression models. Post-prandial GIPAUC was affected by degree of adiposity (P=0.026), with cats in the leaner state secreting increased GIPAUC compared to the cats in the obese state. There was also an effect of diet on GIPAUC, with cats on RCD diet having a higher median GIPAUC than the cats on MD (P=0.02). This suggests that dietary macronutrient content is important in determining GIP responses not only acutely but also on a long-term basis. There was an effect of adiposity on baseline GLP-1, with cats in the obese state having higher GLP-1 concentrations than cats in the leaner state (p=0.02). There was no effect of diet or adiposity of GLP-1AUC. Further investigation is needed to understand the specific nutrients that effect changes in GIP secretion, and specific hormonal changes that accompany weight loss of the maintenance of a lean body condition.
Chen Gilor, DVM, PhD (Advisor)
68 p.

Recommended Citations

Citations

  • McCool, K. E. (2016). The effect of diet and adiposity on the secretion of incretin hormones in cats [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1471605344

    APA Style (7th edition)

  • McCool, Katherine. The effect of diet and adiposity on the secretion of incretin hormones in cats . 2016. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1471605344.

    MLA Style (8th edition)

  • McCool, Katherine. "The effect of diet and adiposity on the secretion of incretin hormones in cats ." Master's thesis, Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1471605344

    Chicago Manual of Style (17th edition)