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Inflammatory Responses to Combinations of: Mental Load, Repetitive Lifting and Subject Personality.

Splittstoesser, Riley Emiel

Abstract Details

2016, Doctor of Philosophy, Ohio State University, Industrial and Systems Engineering.
The literature was reviewed to identify inflammatory markers found in the blood of subjects suffering from LBP. This information was then used to design an experiment intended to determine the contribution of repetitive lifting, mental load and subject personality to inflammatory responses after exposure. Twenty male subjects were exposed to repetitive lifting combined with a high or low mental workload task for two hours. Plasma, WBC counts, IL-1ß, TNF-a, IL-6, IL-8, IL-10, Substance P, Creatine Kinase, and salivary cortisol were sampled before, immediately post, 2 hours post and 20 hours post exposure. A well-regulated inflammatory response was observed following exposure. There was an initial elevation of IL-6, TNF-a, IL-8 and CK while the composition of plasma WBCs shifted in favor of granulocytes. 20 hours post exposure, CK concentrations have peaked and circulating granulocytes returned to normal. However, granulocytes are expected to live longer than 20 hours and therefore may still be active at sites of tissue trauma. In an industrial setting, 20 hours post lifting exposure would correspond to a worker returning to work the next day and creates conditions for cumulative lifting and inflammatory exposures. Interactions were noted between subject personality, mental load and inflammatory responses. Interactions were also noted between mental load, personality and spinal loading. However, these changes in spinal load did not correspond to changes in inflammatory responses.
William Marras, Ph.D. (Advisor)
Thomas Best, MD, Ph.D. (Committee Member)
Devina Purmessur, Ph.D. (Committee Member)
Safdar Khan, MD (Committee Member)
155 p.

Recommended Citations

Citations

  • Splittstoesser, R. E. (2016). Inflammatory Responses to Combinations of: Mental Load, Repetitive Lifting and Subject Personality. [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1479763594134482

    APA Style (7th edition)

  • Splittstoesser, Riley. Inflammatory Responses to Combinations of: Mental Load, Repetitive Lifting and Subject Personality. 2016. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1479763594134482.

    MLA Style (8th edition)

  • Splittstoesser, Riley. "Inflammatory Responses to Combinations of: Mental Load, Repetitive Lifting and Subject Personality." Doctoral dissertation, Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1479763594134482

    Chicago Manual of Style (17th edition)