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Implications of Breastfeeding in Triple Negative Breast Cancer

Basree, Mustafa M
http://rave.ohiolink.edu/etdc/view?acc_num=osu1492791260508232

Abstract Details

2017, Master of Science, Ohio State University, Anatomy.
Due to high mortality associated with triple negative breast cancer (TNBC), a prevention program has the potential to protect many women against this disease. Recent epidemiological and meta-analysis studies revealed a possible correlation between a lack of breastfeeding and development of TNBC. African-American (AA) women have a disproportionate burden of developing aggressive TNBC, a sub-population with higher parity rates and lower prevalence of breastfeeding. The reasons for why parity and breastfeeding affect breast cancer risk are unclear, but recent studies revealed that the pregnancy-lactation cycle (which leads to remodeling of the mammary glands) alters breast morphology and microenvironment, thereby modifying breast cancer risk. Natural weaning (NW), the gradual cessation of breastfeeding, results in a measured reduction of the ductal structures, termed involution. Conversely, the decision not to breastfeed results in a hastened involution, or abrupt involution (AW). We modeled NW and AW in wild-type mice by restricting breastfeeding to 28 and 7 days respectively. Striking differences in the distribution of cell populations were observed in the mammary glands of AW mice compared to NW mice. Fluorescence activated cell sorting analysis revealed an expansion of the luminal progenitor cells with a concomitant decrease in mammary stem-cell enriched/basal compartment in the glands of the AW cohort. This observation is reminiscent of previous observations in TNBC in both animal models and human pre-neoplastic BRCA1-mutation carrier patients. The AW mammary epithelium is more proliferative, inflammatory, exhibit increased estrogen receptor expression, and is immune active 56 days postpartum. Moreover, we observed more collagen deposition in the AW glands compared with NW, which has been correlated with reduced risk for TNBC. These observations highlight a key difference between the lactating and non-lactating mammary glands at the molecular level that could predispose the AW glands to tumorigenesis. We hope our findings will one day persuade more women to choose breastfeeding as a measure to help prevent TNBC.
Bhuvaneswari Ramaswamy, MD (Committee Chair)
Leone Gustavo, PhD (Advisor)
Kalmar Eileen, PhD (Committee Co-Chair)
Majumder Sarmila, PhD (Committee Member)
McHugh Kirk, PhD (Committee Member)
124 p.
Anatomy and Physiology; Cellular Biology; Molecular Biology; Oncology
breastfeeding; lactation; mammary gland; breast cancer; triple negative breast cancer; cancer prevention

Recommended Citations

Citations

  • Basree, M. M. (2017). Implications of Breastfeeding in Triple Negative Breast Cancer [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492791260508232

    APA Style (7th edition)

  • Basree, Mustafa. Implications of Breastfeeding in Triple Negative Breast Cancer. 2017. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1492791260508232.

    MLA Style (8th edition)

  • Basree, Mustafa. "Implications of Breastfeeding in Triple Negative Breast Cancer." Master's thesis, Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492791260508232

    Chicago Manual of Style (17th edition)

osu1492791260508232
386
© 2017, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.