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Localized Juvenile Spongiotic Gingival Hyperplasia: Clinicopathologic and Microbiologic Correlations

Nguyen, Trang, Nguyen
http://rave.ohiolink.edu/etdc/view?acc_num=osu1498257896007226

Abstract Details

2017, Master of Science, Ohio State University, Dentistry.
Introduction: Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a persistent inflammatory lesion of unknown cause that primarily affects children and young adults. Usually, it involves the maxillary, anterior attached gingiva, and presents as a localized, erythematous, velvety to pebbly plaque that bleeds easily and is nontender. Furthermore, it is refractory to oral hygiene measures. Proposed causes include ectopic junctional epithelium, minor trauma, orthodontic treatment, and tooth eruption. Purpose: The purpose of this prospective investigation was twofold: 1) to identify clinical factors that may be associated with LJSGH and 2) to determine if differences exist between the bacterial profiles of a LJSGH lesion and a classic plaque-induced gingivitis lesion. Methods: Study subjects completed a questionnaire and participated in a clinical examination that included gingival crevicular fluid sampling of both LJSGH and plaque-induced lesions. Descriptive statistics were used to analyze the clinical findings and questionnaire results. The Wilcoxon Signed Rank Sum Test was used to determine if there was a significant difference in plaque scores of teeth with LJSGH and teeth with plaque-induced gingivitis. Gingival crevicular fluid samples were sequenced and analyzed using Bray-Curtis multidimensional scaling and PERMANOVA at the Griffen-Leys Laboratory at The Ohio State University College of Dentistry. Results: Twenty-three patients were recruited to participate in this study; only ten patients met the inclusion criteria and enrolled. 60% of LJSGH lesions occurred in females, and the mean age of individuals was 12.5 ± 2.76. 80% of the study participants identified as Hispanic or Latino. 60% reported frequent consumption of popcorn, a food suspected of causing irritation to the gingiva. 70% of patients demonstrated lip incompetence upon clinical exam. There was no significant difference in plaque scores of teeth associated with LJSGH and those associated with plaque-induced gingivitis (a = 0.05). 60% of LJSGH-associated teeth had a dental defect. 100% of the lesions were biopsied and had a confirmatory histological diagnosis of LJSGH. Bacterial DNA analysis revealed no significant difference between the microbial communities of LJSGH sites and plaque-induced gingivitis sites (a = 0.05). Conclusions: The findings from this study support the current literature on LJSGH. It develops preferentially in the maxillary anterior sextant, and is associated with gingival bleeding. The subgingival bacterial communities of LJSGH lesions are not significantly different from those of classic plaque-induced gingivitis lesions. Further research is necessary to demonstrate a statistically significant relationship between LJSGH and Hispanic predominance, lip incompetence, dental defects, and trauma from food.
Ann Griffen (Advisor)
Catherine Flaitz (Committee Member)
Erin Gross (Committee Member)
57 p.
Dentistry

Recommended Citations

Citations

  • Nguyen, Nguyen, T. (2017). Localized Juvenile Spongiotic Gingival Hyperplasia: Clinicopathologic and Microbiologic Correlations [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1498257896007226

    APA Style (7th edition)

  • Nguyen, Nguyen, Trang. Localized Juvenile Spongiotic Gingival Hyperplasia: Clinicopathologic and Microbiologic Correlations. 2017. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1498257896007226.

    MLA Style (8th edition)

  • Nguyen, Nguyen, Trang. "Localized Juvenile Spongiotic Gingival Hyperplasia: Clinicopathologic and Microbiologic Correlations." Master's thesis, Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1498257896007226

    Chicago Manual of Style (17th edition)

osu1498257896007226
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This open access ETD is published by The Ohio State University and OhioLINK.