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Elucidating the absorption and metabolism of linalool to understand its potential health benefits

Kerns, Angela Nicole
http://rave.ohiolink.edu/etdc/view?acc_num=osu1500566798765732

Abstract Details

2017, Master of Science, Ohio State University, Food Science and Technology.
Linalool, the impact aroma compound present in lavender, is a volatile compound that is prevalent in various foods, flavorings, beverages and perfumes. Lavender essential oil has been used in aromatherapy for centuries, and is known for its sedative and anxiety-reducing effects. There is a proposed pharmacological hypothesis for the beneficial effects of essential oils, which posits that volatile compounds, such as linalool, enter the bloodstream via the nasal or lung mucosa. Following entrance in the blood stream, the active constituent is able to interact and directly affect the central nervous system, resulting in observed changes in mood and physiology. A few studies document the appearance of linalool in blood following ingestion, inhalation and dermal application, supporting our hypothesis that the health benefits of linalool are mediated by the absorption of the compound. However, little is known about the metabolism of linalool following ingestion and inhalation, and it is unknown whether linalool metabolites are responsible for the biological and pharmacological action observed following linalool exposure. Our research aims to better understand linalool absorption and metabolism following ingestion of a linalool beverage or inhalation of volatilized linalool. A small pilot clinical study was conducted wherein participants (n=6) received three different treatments: ingestion of a linalool beverage over 10 minutes, inhalation of linalool orthonasally for 10 minutes and inhalation of linalool retronasally for 10 minutes. Blood samples were taken at various time points (t= 0, 15, 30, 45, 60, 90, 120 minutes), and urine was collected for 24 hours after each treatment. Standards of expected linalool metabolites were synthesized (8-OH-linalool and linalool glucuronide) or purchased, and LC-MS/MS methods were developed to profile the metabolites in blood and urine. Pharmacokinetic parameters for linalool glucuronide in plasma were determined for each of the treatments, and urine analysis revealed linalool glucuronide as the only metabolite detected with our methodology, which may have potential for pharmacological action. Orthonasal and retronasal inhalation treatments led to significantly earlier metabolism of linalool, which was evidenced by an earlier Tmax at 20 minutes for linalool glucuronide in both inhalation treatments compared to Tmax at 37 minutes for ingestion of the linalool beverage. Future work with linalool-containing functional foods may generate insight on mechanisms of health promotion.
Christopher Simons, Ph.D. (Advisor)
Ken Lee, Ph.D. (Advisor)
Luis Rodriguez-Saona, Ph.D. (Committee Member)
100 p.
Food Science

Recommended Citations

Citations

  • Kerns, A. N. (2017). Elucidating the absorption and metabolism of linalool to understand its potential health benefits [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1500566798765732

    APA Style (7th edition)

  • Kerns, Angela. Elucidating the absorption and metabolism of linalool to understand its potential health benefits. 2017. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1500566798765732.

    MLA Style (8th edition)

  • Kerns, Angela. "Elucidating the absorption and metabolism of linalool to understand its potential health benefits." Master's thesis, Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1500566798765732

    Chicago Manual of Style (17th edition)

osu1500566798765732
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This open access ETD is published by The Ohio State University and OhioLINK.