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Matthew Souva - Dissertation.pdf (3.14 MB)

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High Throughput Block Copolymer Nanoparticle Assembly Methods

Souva, Matthew Scott
http://rave.ohiolink.edu/etdc/view?acc_num=osu1503101272745765

Abstract Details

2017, Doctor of Philosophy, Ohio State University, Chemical Engineering.
Nanotechnology achievements have presented novel solutions to problems in energy harvesting, lithographic strategies, and biomedical treatments with development of functional nanoparticles. However, many nanotech demonstrations originate from organic syntheses, limiting translation of hydrophobic materials to aqueous media. Nanoparticle encapsulation within self-assembling amphiphilic block copolymers represents an attractive gateway to water delivery. Unfortunately, most modes of polymer self-assembly are considered at the batch level, with limited translation to scalable technologies and, therefore, a limited horizon for broad application or commercialization. Flow-based adaptations of prior batch efforts represent a significant step toward the development of a truly continuous mode of nanotechnology production. We have demonstrated two distinct routes for block copolymer nanoparticle generation, each transferring amphiphilic polymer from organic solution into water, thus inducing self-assembly. The first technique is a coaxial electrospray process, used to form emulsion droplets for a polymer particle assembly approach with a water-immiscible organic solvent. The second is a flash nanoprecipitation option, in which water-miscible solvent is rapidly mixed with water to induce sudden particle assembly. We have demonstrated the ability to control and improve polymer throughput and, therefore, nanoparticle production rates by manipulating operational parameters specific to each system. In iii addition, we have utilized coaxial electrospray to encapsulate hydrophobic magnetic material within polymer structures, for eventual use in manipulation or imaging technologies. Nanoparticle research applications are limited without sufficient process development to generate adequate amounts of material. Scalable nanomanufacturing efforts are in vein if unable to deliver functional particles in a repeatable, robust manner. Coaxial electrospray and flash nanoprecipitation both represent promising directions for future implementation because they achieve both goals: success on the nanoscale, with production enough for utility at the macroscale.
Jessica Winter (Advisor)
Barbara Wyslouzil (Advisor)
Lisa Hall (Committee Member)
263 p.
Chemical Engineering
Aerosol Particle Formation; Polymer Self-Assembly; Transmission Electron Microscopy; Polymer Science and Engineering; Nanotechnology

Recommended Citations

Citations

  • Souva, M. S. (2017). High Throughput Block Copolymer Nanoparticle Assembly Methods [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1503101272745765

    APA Style (7th edition)

  • Souva, Matthew. High Throughput Block Copolymer Nanoparticle Assembly Methods. 2017. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1503101272745765.

    MLA Style (8th edition)

  • Souva, Matthew. "High Throughput Block Copolymer Nanoparticle Assembly Methods." Doctoral dissertation, Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1503101272745765

    Chicago Manual of Style (17th edition)

osu1503101272745765
366
© 2017, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.