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Measurement and Variation of the Mechanical Environment in Glioblastoma

Calhoun, Mark A, II
http://rave.ohiolink.edu/etdc/view?acc_num=osu1503252735120506

Abstract Details

2017, Doctor of Philosophy, Ohio State University, Biomedical Engineering.
Glioblastoma is a highly lethal brain tumor for which patient survival times have remained around 14 months for the past 40 years. The lethality of the disease is driven by the invasive nature of the tumor, which results in substantial infiltration throughout the brain parenchyma. These cells that are migrating further from the tumor are able to avoid surgical resection and radiotherapy. As a result, this places a greater burden on chemotherapy to eradicate the remaining tumor cells. Most often, temozolomide(TMZ), the gold standard chemotherapeutic, fails to meet this objective and a treatment-resistant tumor recurs, to which the vast majority of patients will succumb. The problem with chemotherapy is two-fold. First, TMZ is a genotoxic drug, so tumor cells that are resistant to DNA damage-induced apoptosis are able to survive and serve as the genetic basis of the recurrent tumor. In order to eliminate enough tumor cells to prevent a recurrent tumor, new drug targets are needed. Combination therapy has been the most effective approach to cancer treatment (i.e. surgery, radiation, and chemotherapy) and it is likely that the future of glioblastoma research will involve additional chemotherapies. Second, drug delivery to the brain is poor because of the blood-brain barrier (BBB). Therefore, this dissertation has characterized and probed the mechanical microenvironment to build towards new drug targets for patient treatment. Additionally, a drug carrier is characterized for its ability to cross the BBB, to improve drug delivery to the brain.
Jessica Winter, PhD (Advisor)
Jose Otero, MD, PhD (Committee Member)
Samir Ghadiali, PhD (Committee Member)
Keith Gooch, PhD (Committee Member)
247 p.
Biomedical Engineering
Biomedical Engineering; Mechanobiology; Tumor Microenvironment; Glioblastoma

Recommended Citations

Citations

  • Calhoun, II, M. A. (2017). Measurement and Variation of the Mechanical Environment in Glioblastoma [Doctoral dissertation, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1503252735120506

    APA Style (7th edition)

  • Calhoun, II, Mark. Measurement and Variation of the Mechanical Environment in Glioblastoma. 2017. Ohio State University, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1503252735120506.

    MLA Style (8th edition)

  • Calhoun, II, Mark. "Measurement and Variation of the Mechanical Environment in Glioblastoma." Doctoral dissertation, Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1503252735120506

    Chicago Manual of Style (17th edition)

osu1503252735120506
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© 2017, some rights reserved.Creative Commons License Measurement and Variation of the Mechanical Environment in Glioblastoma by Mark A Calhoun II is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by The Ohio State University and OhioLINK.