Skip to Main Content
Frequently Asked Questions
Submit an ETD
Global Search Box
Need Help?
Keyword Search
Participating Institutions
Advanced Search
School Logo
Files
File List
Thesis.pdf (1.42 MB)
ETD Abstract Container
Abstract Header
Analysis of Spreading Depolarization as a Traveling Wave in a Neuron-Astrocyte Network
Author Info
Lee, Ray A
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=osu1503308416771087
Abstract Details
Year and Degree
2017, Master of Mathematical Sciences, Ohio State University, Mathematics.
Abstract
We analyze an existing neuron-astrocyte network model of spreading depolarization propagated by extracellular K+. We reduce the model to the form of a bistable diffusion equation in extracellular K+ to understand how key parameters influence the underlying traveling wave solution. Our analysis suggests that, when coupled with the maintenance of astrocytic isopotentiality, increased astrocyte K+ permeability and ``instantaneously"-increased sodium-potassium pump strength effectively augment the resistance of the network to spreading depolarization.
Committee
David Terman (Advisor)
Joseph Tien (Committee Member)
Pages
34 p.
Subject Headings
Mathematics
;
Neurosciences
Keywords
Computational neuroscience
;
spreading depolarization
;
traveling waves
Recommended Citations
Refworks
EndNote
RIS
Mendeley
Citations
Lee, R. A. (2017).
Analysis of Spreading Depolarization as a Traveling Wave in a Neuron-Astrocyte Network
[Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1503308416771087
APA Style (7th edition)
Lee, Ray.
Analysis of Spreading Depolarization as a Traveling Wave in a Neuron-Astrocyte Network.
2017. Ohio State University, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=osu1503308416771087.
MLA Style (8th edition)
Lee, Ray. "Analysis of Spreading Depolarization as a Traveling Wave in a Neuron-Astrocyte Network." Master's thesis, Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1503308416771087
Chicago Manual of Style (17th edition)
Abstract Footer
Document number:
osu1503308416771087
Download Count:
323
Copyright Info
© 2017, all rights reserved.
This open access ETD is published by The Ohio State University and OhioLINK.