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Da'Sean Green-Thesis.pdf (1.54 MB)

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Trehalose-Stabilized Polymer Assemblies for Drug Delivery Applications

Green, Da'Sean Edward
http://rave.ohiolink.edu/etdc/view?acc_num=osu150332742091042

Abstract Details

2017, Master of Science, Ohio State University, Chemistry.
a-D-glucopyranosyl-(1¿1)-a-D-glucopyranoside, more commonly known as trehalose, is a natural alpha-linked disaccharide that was first isolated from a substance made by weevils. Trehalose is an essential component in anhydrobiosis, which is the ability to withstand prolonged periods of desiccation in some plants and animals. This sugar is thought to form a gel phase as cells dehydrate, which prevents disruption of internal cell organelles, by effectively splintting them in position. Rehydration then allows normal cellular activity to be resumed without the major, lethal damage that would normally follow a dehydration/rehydration cycle. Utilizing RAFT polymerization, we synthesized a CTA derivative that give us access to the aminooxy ether functional group which we then conjugated to a modified trehalose in order to generate sugar-polymer multi-block polymers. We intend to use these trehalose multi-block polymers as an improved drug carrier for drug delivery. There have been studies on using various sugars, trehalose among them, as cryoprotectants for liposomes to see which cryoprotectant would yield greater quantity of useable liposomes upon rehydration. Thus, the hope for these trehalose multi-block polymers is to use them as a drug delivery agent that will be able to sustain dehydration without use of an additional cryoprotectant.
Dennis Bong, Ph.D (Advisor)
Psaras McGrier, Ph.D (Committee Member)
87 p.
Chemistry
Polymers; Drug delivery; Trehalose

Recommended Citations

Citations

  • Green, D. E. (2017). Trehalose-Stabilized Polymer Assemblies for Drug Delivery Applications [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu150332742091042

    APA Style (7th edition)

  • Green, Da'Sean. Trehalose-Stabilized Polymer Assemblies for Drug Delivery Applications. 2017. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu150332742091042.

    MLA Style (8th edition)

  • Green, Da'Sean. "Trehalose-Stabilized Polymer Assemblies for Drug Delivery Applications." Master's thesis, Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu150332742091042

    Chicago Manual of Style (17th edition)

osu150332742091042
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This open access ETD is published by The Ohio State University and OhioLINK.