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Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms in Vitreoretinal Disease

Van Law, Heather
http://rave.ohiolink.edu/etdc/view?acc_num=osu1523296832882977

Abstract Details

2018, Master of Science, Ohio State University, Vision Science.
Proliferative Vitreoretinopathy (PVR) is an inflammatory, fibrotic condition that develops after 5-10% of rhegmatogenous retinal detachments and is the main cause of failure of retinal detachment repair.1-4 Though there are several known risk factors for PVR, it is not known which patients will develop PVR following RD surgery. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that is an important mediator of inflammation throughout the body.5-8 MIF polymorphisms, specifically –794 CATT repeat (rs5844572) and –173 G/C promoter (rs755622), lead to an increased expression of MIF and have been linked with disease severity in a multitude of systemic diseases including systemic lupus erythematosus (SLE)9, rheumatoid arthritis (RA)10-12, juvenile idiopathic arthritis (JIA)13, sarcoidosis14, scleroderma15, and spinal cord injury, among others. MIF vitreous levels are shown to be elevated in the vitreous and subretinal fluid of patients with PVR.16,17 Our research aims to determine if the presence of specific MIF promoter polymorphisms leads to an increased risk of PVR development or ERM formation.
Colleen Cebulla (Advisor)
Mohamed Abdel-Rahman (Committee Member)
Gladys Mitchell (Committee Member)
65 p.
Ophthalmology

Recommended Citations

Citations

  • Van Law, H. (2018). Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms in Vitreoretinal Disease [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523296832882977

    APA Style (7th edition)

  • Van Law, Heather. Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms in Vitreoretinal Disease. 2018. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1523296832882977.

    MLA Style (8th edition)

  • Van Law, Heather. "Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms in Vitreoretinal Disease." Master's thesis, Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523296832882977

    Chicago Manual of Style (17th edition)

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This open access ETD is published by The Ohio State University and OhioLINK.