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Pengfei_MS thesis.pdf (2.92 MB)

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Sustained Release of Anti-VEGF from Injectable Devices for Treating Wet Age-Related Macular Degeneration

Jiang, Pengfei
http://rave.ohiolink.edu/etdc/view?acc_num=osu1523875289847083

Abstract Details

2018, Master of Science, Ohio State University, Chemical Engineering.
Age-related macular degeneration (AMD) is the fourth most common cause of blindness in the world. There are more than 11 million people diagnosed with AMD in the United States. It is estimated that this number will double in 2050. Accordingly, much work has been done understanding disease pathogenesis and developing therapeutic methods. It is widely noted that overexpression of vascular endothelial growth factor (VEGF) along with aging stimulates neovascularization in the choroid, which leads to irreversible damages to the retina during bleeding and scarring of newly formed blood vessels. The current gold standard treatment for wet AMD is a monthly intravitreal injection of anti-VEGF such as bevacizumab or ranibizumab to inhibit VEGF and to prevent angiogenesis. However, frequent injections often lead to infection, elevated intraocular pressure and rhegmatogenous retinal detachment, as well as issues with patient compliance. Therefore, there is a need for an improved therapeutic approach for the treatment of wet AMD. To address the problems associated with the current clinical treatment, we have developed several novel devices made from two polymeric materials to extend the period of drug release and to avoid the side effects associated with the monthly anti-VEGF injection. Our novel devices are in two different forms, microparticle and capsule. The preliminary results demonstrate that the devices enable the longer-term local drug administration as compared to previously reported devices. This study provides an alternative method to raise the therapeutic efficacy and further improve the quality of life for people diagnosed with wet AMD.
Katelyn Swindle-Reilly (Advisor)
Eduardo Reátegui (Committee Member)
Chemical Engineering

Recommended Citations

Citations

  • Jiang, P. (2018). Sustained Release of Anti-VEGF from Injectable Devices for Treating Wet Age-Related Macular Degeneration [Master's thesis, Ohio State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523875289847083

    APA Style (7th edition)

  • Jiang, Pengfei. Sustained Release of Anti-VEGF from Injectable Devices for Treating Wet Age-Related Macular Degeneration. 2018. Ohio State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=osu1523875289847083.

    MLA Style (8th edition)

  • Jiang, Pengfei. "Sustained Release of Anti-VEGF from Injectable Devices for Treating Wet Age-Related Macular Degeneration." Master's thesis, Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523875289847083

    Chicago Manual of Style (17th edition)

osu1523875289847083
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© 2018, some rights reserved.Creative Commons License Sustained Release of Anti-VEGF from Injectable Devices for Treating Wet Age-Related Macular Degeneration by Pengfei Jiang is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by The Ohio State University and OhioLINK.